Guidobono F, Netti C, Pecile A, Gritti I, Mancia M
Department of Pharmacology, University of Milan, Italy.
Neuropeptides. 1987 Oct;10(3):265-73. doi: 10.1016/0143-4179(87)90077-1.
Calcitonin (CT) binding site distribution has been studied in the cat CNS. The autoradiographic analyses of [125I]-eelCT (ECT) binding showed high density of silver grains in the mesencephalic PAG, in the raphe nuclei and in the dorsal horns, laminae I, IV, V, and VI, where ECT may act to inhibit nociceptive transmission. Other binding-rich areas included the caudatus, the amygdala, the hypothalamus, the substantia nigra, the locus coeruleus and the formatio reticularis mesencephalica. Medium to low density was seen, amongst other areas in the cortex piriformis, the hippocampus, the medial and intralaminar thalamus and the tractus spino-thalamicus. ECT binding site distribution revealed essentially homologous locations in the cat and rat CNS. At difference, the presence of binding in the piriform cortex and in discrete thalamic nuclei suggests a widespread involvement of ECT in a variety of central functions in addition to what already demonstrated.
已对猫中枢神经系统中降钙素（CT）结合位点的分布进行了研究。对[125I] - 鳗鱼降钙素（ECT）结合的放射自显影分析显示，在中脑导水管周围灰质、中缝核以及背角的I、IV、V和VI层中有高密度的银颗粒，ECT可能在此处发挥抑制伤害性感受传递的作用。其他富含结合位点的区域包括尾状核、杏仁核、下丘脑、黑质、蓝斑和中脑网状结构。在梨状皮质、海马、内侧和板内核丘脑以及脊髓丘脑束等其他区域观察到中低密度。ECT结合位点分布在猫和大鼠中枢神经系统中显示出基本同源的位置。不同的是，梨状皮质和离散丘脑核中存在结合表明，除了已证明的功能外，ECT广泛参与多种中枢功能。
