肿瘤学中的氟代脱氧葡萄糖全身正电子发射断层显像/磁共振成像：一项系统综述
FDG Whole-Body PET/MRI in Oncology: a Systematic Review.
作者信息
Kwon Hyun Woo, Becker Ann-Katharina, Goo Jin Mo, Cheon Gi Jeong
机构信息
Department of Nuclear Medicine, Soonchunhyang University Hospital, Cheonan, South Korea.
Rheinisch Westfälische Technische Hochschule Aachen University, Aachen, Germany.
出版信息
Nucl Med Mol Imaging. 2017 Mar;51(1):22-31. doi: 10.1007/s13139-016-0411-3. Epub 2016 Apr 7.
Abstract
The recent advance in hybrid imaging techniques enables offering simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) in various clinical fields. F-fluorodeoxyglucose (FDG) PET has been widely used for diagnosis and evaluation of oncologic patients. The growing evidence from research and clinical experiences demonstrated that PET/MRI with FDG can provide comparable or superior diagnostic performance more than conventional radiological imaging such as computed tomography (CT), MRI or PET/CT in various cancers. Combined analysis using structural information and functional/molecular information of tumors can draw additional diagnostic information based on PET/MRI. Further studies including determination of the diagnostic efficacy, optimizing the examination protocol, and analysis of the hybrid imaging results is necessary for extending the FDG PET/MRI application in clinical oncology.
摘要
混合成像技术的最新进展使得在各个临床领域能够同时进行正电子发射断层扫描（PET）/磁共振成像（MRI）。F-氟脱氧葡萄糖（FDG）PET已广泛用于肿瘤患者的诊断和评估。来自研究和临床经验的越来越多的证据表明，FDG PET/MRI在各种癌症中能够提供比传统放射成像（如计算机断层扫描（CT）、MRI或PET/CT）相当或更优的诊断性能。利用肿瘤的结构信息和功能/分子信息进行联合分析可以基于PET/MRI获取更多诊断信息。为了扩大FDG PET/MRI在临床肿瘤学中的应用，有必要进行进一步的研究，包括确定诊断效能、优化检查方案以及分析混合成像结果。
相似文献
1
FDG Whole-Body PET/MRI in Oncology: a Systematic Review.肿瘤学中的氟代脱氧葡萄糖全身正电子发射断层显像/磁共振成像：一项系统综述
Nucl Med Mol Imaging. 2017 Mar;51(1):22-31. doi: 10.1007/s13139-016-0411-3. Epub 2016 Apr 7.
2
Comprehensive Oncologic Imaging in Infants and Preschool Children With Substantially Reduced Radiation Exposure Using Combined Simultaneous ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging: A Direct Comparison to ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.使用联合¹⁸F-氟代脱氧葡萄糖正电子发射断层扫描/磁共振成像技术降低辐射剂量对婴儿和学龄前儿童进行全面肿瘤成像：与¹⁸F-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描的直接比较。
Invest Radiol. 2016 Jan;51(1):7-14. doi: 10.1097/RLI.0000000000000200.
3
Simultaneous whole body (18)F-fluorodeoxyglucose positron emission tomography magnetic resonance imaging for evaluation of pediatric cancer: Preliminary experience and comparison with (18)F-fluorodeoxyglucose positron emission tomography computed tomography.用于评估儿童癌症的同时全身（18）F-氟脱氧葡萄糖正电子发射断层扫描磁共振成像：初步经验及与（18）F-氟脱氧葡萄糖正电子发射断层扫描计算机断层扫描的比较
World J Radiol. 2016 Mar 28;8(3):322-30. doi: 10.4329/wjr.v8.i3.322.
4
Evaluation of diagnostic performance of whole-body simultaneous PET/MRI in pediatric lymphoma.儿童淋巴瘤全身同步PET/MRI诊断性能评估
Pediatr Radiol. 2016 Aug;46(9):1258-68. doi: 10.1007/s00247-016-3601-3. Epub 2016 Mar 22.
5
More advantages in detecting bone and soft tissue metastases from prostate cancer using F-PSMA PET/CT.使用F-PSMA PET/CT检测前列腺癌骨和软组织转移方面有更多优势。
Hell J Nucl Med. 2019 Jan-Apr;22(1):6-9. doi: 10.1967/s002449910952. Epub 2019 Mar 7.
6
A prospective diagnostic accuracy study of 18F-fluorodeoxyglucose positron emission tomography/computed tomography, multidetector row computed tomography, and magnetic resonance imaging in primary diagnosis and staging of pancreatic cancer.前瞻性诊断准确性研究 18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描、多排计算机断层扫描和磁共振成像在胰腺癌的初步诊断和分期中的应用。
Ann Surg. 2009 Dec;250(6):957-63. doi: 10.1097/SLA.0b013e3181b2fafa.
7
Indeterminate Findings on Oncologic PET/CT: What Difference Does PET/MRI Make?肿瘤PET/CT的不确定结果：PET/MRI能带来什么不同？
Nucl Med Mol Imaging. 2016 Dec;50(4):292-299. doi: 10.1007/s13139-016-0405-1. Epub 2016 Feb 22.
8
Hybrid imaging for detection of carcinoma of unknown primary: A preliminary comparison trial of whole-body PET/MRI versus PET/CT.用于检测原发灶不明癌的混合成像：全身PET/MRI与PET/CT的初步比较试验
Eur J Radiol. 2016 Nov;85(11):1941-1947. doi: 10.1016/j.ejrad.2016.08.020. Epub 2016 Aug 31.
9
FDG-PET/CT and MRI for Evaluation of Pathologic Response to Neoadjuvant Chemotherapy in Patients With Breast Cancer: A Meta-Analysis of Diagnostic Accuracy Studies.氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）与磁共振成像（MRI）用于评估乳腺癌患者新辅助化疗后的病理反应：诊断准确性研究的荟萃分析
Oncologist. 2016 Aug;21(8):931-9. doi: 10.1634/theoncologist.2015-0353. Epub 2016 Jul 8.
10
Performance of whole-body integrated 18F-FDG PET/MR in comparison to PET/CT for evaluation of malignant bone lesions.全身一体化18F-FDG PET/MR与PET/CT在评估恶性骨病变方面的性能比较。
J Nucl Med. 2014 Feb;55(2):191-7. doi: 10.2967/jnumed.113.123646. Epub 2013 Dec 5.
引用本文的文献
1
Deuterium Metabolic Imaging of the Brain Using 2-Deoxy-2-[H]-d-glucose: A Non-ionizing [F]FDG Alternative.使用2-脱氧-2-[H]-D-葡萄糖进行脑氘代谢成像：一种非电离的[F]FDG替代方法。
JACS Au. 2025 Feb 6;5(2):571-577. doi: 10.1021/jacsau.4c00888. eCollection 2025 Feb 24.
2
Lung imaging methods: indications, strengths and limitations.肺部成像方法：适应症、优势与局限性。
Breathe (Sheff). 2024 Oct 1;20(3):230127. doi: 10.1183/20734735.0127-2023. eCollection 2024 Oct.
3
Integrating Imaging and Circulating Tumor DNA Features for Predicting Patient Outcomes.整合影像学和循环肿瘤DNA特征以预测患者预后。
Cancers (Basel). 2024 May 15;16(10):1879. doi: 10.3390/cancers16101879.
4
Improved automated tumor segmentation in whole-body 3D scans using multi-directional 2D projection-based priors.利用基于多方向二维投影的先验信息改进全身三维扫描中的自动肿瘤分割。
Heliyon. 2024 Feb 15;10(4):e26414. doi: 10.1016/j.heliyon.2024.e26414. eCollection 2024 Feb 29.
5
PET/MRI and Novel Targets for Breast Cancer.正电子发射断层显像/磁共振成像与乳腺癌的新型靶点
Biomedicines. 2024 Jan 12;12(1):172. doi: 10.3390/biomedicines12010172.
6
Introduction to Special Issue Imaging in Cancer Diagnosis.癌症诊断中的影像学专题介绍。
Tomography. 2024 Jan 15;10(1):101-104. doi: 10.3390/tomography10010009.
7
New Trends and Advances in MRI and PET Hybrid Imaging in Diagnostics.MRI与PET融合成像在诊断中的新趋势与进展
Diagnostics (Basel). 2023 Sep 13;13(18):2936. doi: 10.3390/diagnostics13182936.
8
Comparison of F-FDG PET/MR and PET/CT for pretreatment TNM staging of hilar cholangiocarcinoma.18F-氟代脱氧葡萄糖正电子发射断层扫描/磁共振成像（F-FDG PET/MR）与正电子发射断层扫描/计算机断层扫描（PET/CT）在肝门部胆管癌术前TNM分期中的比较
Abdom Radiol (NY). 2023 Aug;48(8):2537-2546. doi: 10.1007/s00261-023-03925-x. Epub 2023 May 13.
9
Lymph Node Imaging in Patients with Primary Breast Cancer: Concurrent Diagnostic Tools.原发性乳腺癌患者的淋巴结成像：同时应用的诊断工具。
Oncologist. 2020 Feb;25(2):e231-e242. doi: 10.1634/theoncologist.2019-0427. Epub 2019 Oct 14.
10
The role of radiological and hybrid imaging for muscle metastases: a systematic review.放射影像学和杂交成像在肌肉转移瘤中的作用：系统评价。
Eur Radiol. 2020 Apr;30(4):2209-2219. doi: 10.1007/s00330-019-06555-4. Epub 2019 Dec 13.
本文引用的文献
1
Clinical utility of 18F-FDG-PET/MR for preoperative breast cancer staging.18F-FDG-PET/MR在乳腺癌术前分期中的临床应用价值。
Eur Radiol. 2016 Jul;26(7):2297-307. doi: 10.1007/s00330-015-4054-z. Epub 2015 Oct 17.
2
TNM Staging of Non-Small Cell Lung Cancer: Comparison of PET/MR and PET/CT.非小细胞肺癌的 TNM 分期：PET/MR 与 PET/CT 的比较。
J Nucl Med. 2016 Jan;57(1):21-6. doi: 10.2967/jnumed.115.162040. Epub 2015 Oct 15.
3
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.2015年美国甲状腺协会成人甲状腺结节和分化型甲状腺癌管理指南：美国甲状腺协会甲状腺结节和分化型甲状腺癌指南工作组
Thyroid. 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020.
4
Comparison of positron emission tomography diffusion-weighted imaging (PET/DWI) registration quality in a PET/MR scanner: Zoomed DWI vs. Conventional DWI.PET/MR扫描仪中 正电子发射断层扫描扩散加权成像（PET/DWI）配准质量的比较：放大DWI与传统DWI
J Magn Reson Imaging. 2016 Apr;43(4):853-8. doi: 10.1002/jmri.25059. Epub 2015 Oct 6.
5
[(18)F]FDG PET/CT outperforms [(18)F]FDG PET/MRI in differentiated thyroid cancer.在分化型甲状腺癌中，[（18）F]氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（[（18）F]FDG PET/CT）比[（18）F]氟代脱氧葡萄糖正电子发射断层扫描/磁共振成像（[（18）F]FDG PET/MRI）表现更优。
Eur J Nucl Med Mol Imaging. 2016 Feb;43(2):212-220. doi: 10.1007/s00259-015-3195-2. Epub 2015 Sep 29.
6
18F-FDG-PET/MR increases diagnostic confidence in detection of bone metastases compared with 18F-FDG-PET/CT.与18F-FDG-PET/CT相比，18F-FDG-PET/MR提高了检测骨转移的诊断置信度。
Nucl Med Commun. 2015 Dec;36(12):1165-73. doi: 10.1097/MNM.0000000000000387.
7
Accuracy of [18F]FDG PET/MRI for the Detection of Liver Metastases.[18F]氟代脱氧葡萄糖正电子发射断层扫描/磁共振成像检测肝转移灶的准确性
PLoS One. 2015 Sep 3;10(9):e0137285. doi: 10.1371/journal.pone.0137285. eCollection 2015.
8
Implementation of FAST-PET/MRI for whole-body staging of female patients with recurrent pelvic malignancies: A comparison to PET/CT.FAST-PET/MRI在复发性盆腔恶性肿瘤女性患者全身分期中的应用：与PET/CT的比较
Eur J Radiol. 2015 Nov;84(11):2097-102. doi: 10.1016/j.ejrad.2015.08.010. Epub 2015 Aug 20.
9
Comprehensive Oncologic Imaging in Infants and Preschool Children With Substantially Reduced Radiation Exposure Using Combined Simultaneous ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging: A Direct Comparison to ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.使用联合¹⁸F-氟代脱氧葡萄糖正电子发射断层扫描/磁共振成像技术降低辐射剂量对婴儿和学龄前儿童进行全面肿瘤成像：与¹⁸F-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描的直接比较。
Invest Radiol. 2016 Jan;51(1):7-14. doi: 10.1097/RLI.0000000000000200.
10
Initial Experience of 18F-FDG PET/MRI in Thymic Epithelial Tumors: Morphologic, Functional, and Metabolic Biomarkers.18F-FDG PET/MRI 在胸腺瘤中的初步应用：形态学、功能和代谢生物标志物。
Clin Nucl Med. 2016 Jan;41(1):8-14. doi: 10.1097/RLU.0000000000000946.
Zotero 插件