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一种用于洗脱、校准和分配高锝[99Tc]酸盐的计算机控制自动分配器。

A computer controlled automated dispensor for the eluting, calibrating and dispensing of 99Tcm-pertechnetate.

作者信息

Fueger G F, Kriwetz G, Gaertner K, Barowitsch C

机构信息

Department of Radiology, Karl Franzens Universitaet, Graz, Austria.

出版信息

Nucl Med Commun. 1987 Sep;8(9):733-49. doi: 10.1097/00006231-198709000-00005.

DOI:10.1097/00006231-198709000-00005
PMID:2825092
Abstract

This paper describes an automated 99Tcm-Dispensor, a computer controlled device for the programmed, automated elution of 99Tcm-sodium pertechnetate, its calibration, metered delivery and dilution. The elution can be programmed up to 7 days in advance. The total radioactivity of the eluate is assayed by a semiconductor counter integrated in the shielding of the pertechnetate reservoir. The volume of eluate actually available for dispensing is measured by capacitance and is monitored continuously. The specific concentration is calculated from total activity and volume, and is corrected for decay prior to each delivery. All activity bearing sections are shielded by lead-antimony covers specified to attenuate the radiation from generators up to 2 Ci 99Mo/99Tcm. The labelling vials are inserted into the dispensing chamber within a shielding vessel manually. The sodium pertechnetate solution is dispensed prior to the optional additional delivery of normal saline. The Tc-Dispensor maintains sterility, guards against accidental radioactive contamination, and is suited to reduce the radiation burden of personnel. All operations are recorded by the computer enabling the print-out of protocols. We found the Tc-Dispensor safe, precise and accurate.

摘要

本文介绍了一种自动化的99锝分配器,这是一种计算机控制的设备,用于对高锝酸钠进行程序化自动洗脱、校准、定量输送和稀释。洗脱程序可提前7天设定。洗脱液的总放射性由集成在高锝酸盐储存器屏蔽层中的半导体计数器进行测定。实际可供分配的洗脱液体积通过电容测量,并进行连续监测。比浓度由总活度和体积计算得出,并在每次输送前对衰变进行校正。所有带有放射性的部分均由铅锑盖屏蔽,该屏蔽盖经指定可衰减来自高达2居里99钼/99锝发生器的辐射。标记瓶需手动插入屏蔽容器内的分配腔室。在可选择额外输送生理盐水之前,先分配高锝酸钠溶液。锝分配器可保持无菌状态,防止意外放射性污染,并且有助于减轻人员的辐射负担。所有操作均由计算机记录,可打印出实验方案。我们发现该锝分配器安全、精确且准确。

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Nucl Med Commun. 1987 Sep;8(9):733-49. doi: 10.1097/00006231-198709000-00005.
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