Dikensoy Ebru, Balat Ozcan, Cebesoy Bahar, Ozkur Ayhan, Cicek Hulya, Can Gunay
Department of Obstetrics and Gynecology, Gaziantep University, Gaziantep, Turkey.
J Obstet Gynaecol Res. 2008 Aug;34(4):494-8. doi: 10.1111/j.1447-0756.2008.00814.x.
The aim of the present study was to determine whether fasting during Ramadan causes ketonemia and/or ketonuria and their effects on fetal intrauterine development.
Thirty-six consecutive healthy women with uncomplicated pregnancies of >or=20 weeks of gestation who were fasting during Ramadan were included in the study group (group 1). The control group (group 2) consisted of 29 healthy pregnant women who were not fasting. Doppler ultrasonography was performed in all subjects in the beginning and at the end of Ramadan to evaluate the changes in the following measurements: fetal biparietal diameter; fetal femur length; and estimated fetal body weight. Fetal biophysical profile, amniotic fluid index, and umbilical artery systole/diastole ratio were measured in the beginning and at the end of Ramadan. Effects of fasting on the mother were evaluated by measuring serum concentrations of 3ss hydroxybutyrate and glucose, and urinary concentration of ketone. Subjects with any of the followings were excluded: diabetes; thyroid dysfunction; Cushing's syndrome; adrenal disease; pre-eclampsia; and multiple pregnancy.
The mean duration of fasting in the study group was 18 +/- 2.1 days. The mean maternal glucose level was significantly lower in the study group than in the control group (P = 0.003). No statistically significant differences were found between the two groups in the comparisons of other parameters.
We concluded that fasting during Ramadan does not lead to maternal ketonemia or ketonuria in pregnant women. In addition, fasting during Ramadan has no significant adverse effect on intrauterine fetal development or the fetus's health.
本研究旨在确定斋月期间禁食是否会导致酮血症和/或酮尿症及其对胎儿宫内发育的影响。
研究组（第1组）纳入了36名连续妊娠超过或等于20周且在斋月期间禁食的健康未合并并发症的孕妇。对照组（第2组）由29名未禁食的健康孕妇组成。在斋月开始和结束时对所有受试者进行多普勒超声检查，以评估以下测量值的变化：胎儿双顶径；胎儿股骨长度；以及估计胎儿体重。在斋月开始和结束时测量胎儿生物物理评分、羊水指数和脐动脉收缩期/舒张期比值。通过测量血清3β-羟基丁酸和葡萄糖浓度以及尿酮浓度来评估禁食对母亲的影响。排除患有以下任何一种疾病的受试者：糖尿病；甲状腺功能障碍；库欣综合征；肾上腺疾病；先兆子痫；以及多胎妊娠。
研究组的平均禁食时长为18±2.1天。研究组孕妇的平均血糖水平显著低于对照组（P = 0.003）。两组在其他参数比较中未发现统计学上的显著差异。
我们得出结论，斋月期间禁食不会导致孕妇出现母体酮血症或酮尿症。此外，斋月期间禁食对胎儿宫内发育或胎儿健康没有显著不良影响。
