Wang Huijuan, An Xuehan, Deng Xiaojuan, Ding Guosheng
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P.R. China.
Analysis Center, Tianjin University, Tianjin, P.R. China.
Electrophoresis. 2017 May;38(9-10):1374-1382. doi: 10.1002/elps.201600419. Epub 2017 Mar 23.
A facile, mild method for the preparation of teicoplanin (TE) modified Fe O microparticles (MPs) employing polydopamine (PDA) layer as a versatile secondary reaction platform was developed. The synthesized magnetic MPs (Fe O @PDA@TE) were characterized by various characterization techniques, such as TEM, zeta potential etc, to affirm the successful modification of TE to magnetic Fe O MPs. Using the as-synthesized materials as chiral adsorbents, efficient chiral separation of representative racemic compounds was successfully achieved. Due to the magnetic responsivity, the materials were easily isolated from the racemic solutions under an external magnetic field and could be readily reused for at least three times. Thus, the well-prepared functional magnetic MPs have great potential in preparative chiral separation.
开发了一种简便、温和的方法，以聚多巴胺（PDA）层作为通用的二次反应平台来制备替考拉宁（TE）修饰的Fe₃O₄微粒（MPs）。通过各种表征技术，如透射电子显微镜（TEM）、zeta电位等对合成的磁性MPs（Fe₃O₄@PDA@TE）进行表征，以确认TE成功修饰到磁性Fe₃O₄ MPs上。使用合成的材料作为手性吸附剂，成功实现了代表性外消旋化合物的高效手性分离。由于具有磁响应性，这些材料在外部磁场下很容易从外消旋溶液中分离出来，并且可以很容易地重复使用至少三次。因此，制备良好的功能性磁性MPs在制备性手性分离方面具有巨大潜力。
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