Northeastern University at Qinhuangdao, School of Control Engineering, Qinhuangdao, China.
University of Washington, Department of Bioengineering, Seattle, Washington, United States.
J Biomed Opt. 2017 Mar 1;22(3):36002. doi: 10.1117/1.JBO.22.3.036002.
We demonstrate a quasinoncontact photoacoustic imaging method using a homodyne interferometer with a long coherence length laser. The generated photoacoustic signal is detected by a system that is locked at its maximum sensitivity through the use of balanced detection and zero-crossing triggering. The balanced detector is substantially equalized, so its output is zero when the system reaches the maximum sensitivity. The synchronization approach is used to trigger the excitation and detection of the photoacoustic signal. The system is immune to ambient vibrations. A thin water layer on the sample surface is used to reduce the effect of the rough tissue surface. The performance of the system is demonstrated by in vivo imaging of the microvasculature in mouse ears.
我们展示了一种使用具有长相干长度激光的外差干涉仪的准非接触光声成像方法。所产生的光声信号由通过使用平衡检测和过零触发将系统锁定在最大灵敏度的系统检测。平衡探测器被充分地均衡，因此当系统达到最大灵敏度时，其输出为零。同步方法用于触发光声信号的激发和检测。该系统对环境振动具有免疫力。在样品表面上的薄水层用于减小粗糙组织表面的影响。通过对小鼠耳朵中的微血管进行体内成像来证明系统的性能。
