Ding Ning, Jiang Huiwen, Xiang Ben, Yu Yao, Ji Cheng, Liu Jian, Zhao Yuqian, Luan Jingmin, Yang Yanqiu, Wang Yi, Ma Zhenhe
College of Information Science and Engineering, Northeastern University, Shenyang 110819, China.
School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, china.
Photoacoustics. 2024 Jul 1;38:100631. doi: 10.1016/j.pacs.2024.100631. eCollection 2024 Aug.
We proposed a non-contact photoacoustic (PA) detection method using spectral domain optical coherence tomography (SDOCT). Two interference spectrums (A-lines) were acquired before and after the PA excitation with SDOCT. PA signal propagated within the sample causing the vibration. The vibration inner the sample introduced phase change between the acquired two A-lines. Thus, the PA signal can be detected by evaluating the difference in phase between the two A-lines. Based on the method, an OCT-PAM dual-mode imaging system was constructed. In the system, SDOCT served as the detection unit for PAM. Thus, the combination of the two imaging modalities was simplified. Another advantage of the system is that it realizes non-contact all-optic detection, which is attractive for biomedical imaging. Using the system, we imaged phantoms of carbon fibers, asparagus leaves and human hairs. Furthermore, the cortical vasculature of rat was imaged and the flow status was evaluated quantitatively.
我们提出了一种使用光谱域光学相干断层扫描（SDOCT）的非接触式光声（PA）检测方法。利用SDOCT在光声激发前后采集两条干涉光谱（A线）。光声信号在样品中传播引起振动。样品内部的振动在采集的两条A线之间引入了相位变化。因此，通过评估两条A线之间的相位差可以检测光声信号。基于该方法，构建了一个OCT-PAM双模成像系统。在该系统中，SDOCT作为光声显微镜（PAM）的检测单元。因此，简化了两种成像模式的组合。该系统的另一个优点是它实现了非接触式全光学检测，这对生物医学成像具有吸引力。使用该系统，我们对碳纤维、芦笋叶和人发的模型进行了成像。此外，对大鼠的皮质血管进行了成像，并对血流状态进行了定量评估。
