Howardy-Hansen P, Møller J, Hansen B
Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Denmark.
Acta Anaesthesiol Scand. 1987 Oct;31(7):642-4. doi: 10.1111/j.1399-6576.1987.tb02636.x.
The influence of pretreatment with atracurium on neuromuscular transmission was evaluated in 60 healthy volunteers using train-of-four (TOF) nerve stimulation and measurement of respiratory rate (RR), vital capacity (VC), inspiratory force (IF), and peak expiratory flow (PEF). The subjects were randomly allocated to one of four groups: Group I received atracurium 0.02 mg/kg, Group II 0.03 mg/kg, Group III 0.04 mg/kg, and Group IV atracurium 0.05 mg/kg. TOF ratio decreased significantly in all four groups. There was, however, no difference between the groups after injection. PEF decreased significantly in all four groups, VC decreased in Groups I and IV, and RF increased significantly only in Group IV. Three subjects (5%) had shallow, frequent respiration; however, none needed respiratory support. The majority of the volunteers experienced blurring of vision and heavy eyelids: 82% and 67%, respectively. All subjects were able to sustain head lift for 10 s or more after atracurium. Careful observation of respiration is necessary, especially when using the higher doses of atracurium.
使用四个成串刺激（TOF）神经刺激以及测量呼吸频率（RR）、肺活量（VC）、吸气力（IF）和呼气峰值流速（PEF），在60名健康志愿者中评估了阿曲库铵预处理对神经肌肉传递的影响。受试者被随机分配到四组中的一组：第一组接受0.02mg/kg阿曲库铵，第二组接受0.03mg/kg，第三组接受0.04mg/kg，第四组接受0.05mg/kg阿曲库铵。所有四组的TOF比率均显著下降。然而，注射后各组之间没有差异。所有四组的PEF均显著下降，第一组和第四组的VC下降，仅第四组的RF显著增加。三名受试者（5%）呼吸浅快；然而，无人需要呼吸支持。大多数志愿者出现视力模糊和眼睑沉重：分别为82%和67%。所有受试者在注射阿曲库铵后都能够持续抬头10秒或更长时间。尤其是在使用较高剂量阿曲库铵时，有必要仔细观察呼吸情况。
