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将临床前、鼠类动脉粥样硬化研究的重点从预防转移到晚期干预。

Shifting the Focus of Preclinical, Murine Atherosclerosis Studies From Prevention to Late-Stage Intervention.

机构信息

From the Robert M. Berne Cardiovascular Research Center (R.A.B., D.G., G.K.O.), Department of Biochemistry and Molecular Genetics (R.A.B.), and Department of Molecular Physiology and Biological Physics (D.G., G.K.O.), University of Virginia, Charlottesville.

出版信息

Circ Res. 2017 Mar 3;120(5):775-777. doi: 10.1161/CIRCRESAHA.116.310101.

DOI:10.1161/CIRCRESAHA.116.310101
PMID:28254801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5338643/
Abstract

Could improving the design of preclinical murine atherosclerosis studies help increase the success rate of cardiovascular clinical trials? In this , the authors advocate for a change from prevention to intervention study designs and rigorous lesion analyses which they argue will enhance the translational potential of murine atherosclerosis studies.

摘要

改善临床前鼠动脉粥样硬化研究的设计是否有助于提高心血管临床试验的成功率？在这篇文章中，作者提倡从预防研究设计向干预研究设计转变，并进行严格的病变分析，他们认为这将提高鼠动脉粥样硬化研究的转化潜力。

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