Liu Chih-Yi, Lan Jui, Huang Hsuan-Ying
Division of Pathology, Sijhih Cathay General Hospital, New Taipei City, Taiwan; College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Departments of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Case Rep Pathol. 2017;2017:5370894. doi: 10.1155/2017/5370894. Epub 2017 Jan 31.
. Plexiform fibrohistiocytic tumor is a distinctive mesenchymal neoplasm of low-grade malignancy, with the capacity for biphasic differentiation toward a fibroblastic or histiocyte-like morphology. Clinically, these lesions affect different areas of the body and appear as painless, slowly growing, dermal or subcutaneous masses. To date, only three cases of myxoid variant have been reported in the English literature. . A 45-year-old female patient presented with a subcutaneous nodule in the right popliteal fossa. The initial impression was a benign ganglion cyst. The soft tissue tumor has been treated by local excision. The histopathological and the immunohistochemical findings supported the diagnosis of myxoid plexiform fibrohistiocytic tumor. The postoperative course was uneventful, and the patient received regular follow-up examination. She is alive without any recurrence. . This case demonstrates how to distinguish this distinctive plexiform fibrohistiocytic tumor from other problematic soft tissue tumors. It is also remarkable for its rarely reported extensive myxoid change. Currently, there is no clear-cut correlation between the clinicopathologic findings and the behavior of this unusual variant.
丛状纤维组织细胞瘤是一种独特的低度恶性间叶性肿瘤，具有向成纤维细胞或组织细胞样形态双向分化的能力。临床上，这些病变累及身体不同部位，表现为无痛、生长缓慢的真皮或皮下肿块。迄今为止，英文文献中仅报道过3例黏液样变型。一名45岁女性患者右腘窝出现一个皮下结节。初步诊断为良性腱鞘囊肿。该软组织肿瘤已行局部切除治疗。组织病理学和免疫组化结果支持黏液样丛状纤维组织细胞瘤的诊断。术后过程顺利，患者接受了定期随访检查。她目前存活，无任何复发。该病例展示了如何将这种独特的丛状纤维组织细胞瘤与其他疑难软组织肿瘤相鉴别。其罕见的广泛黏液样改变也很显著。目前，这种不寻常变型的临床病理表现与行为之间尚无明确关联。
