微管在库京病毒复制中的作用。简要报告。
Involvement of microtubules in Kunjin virus replication. Brief report.
作者信息
Hong S S, Ng M L
机构信息
Department of Microbiology, Faculty of Medicine, National University of Singapore.
出版信息
Arch Virol. 1987;97(1-2):115-21. doi: 10.1007/BF01310739.
PMID:2825618
Abstract
Induction of microtubulin paracrystals (Pc) by Kunjin (KUN) virus occurred after 15 hours post-infection and were often associated with convoluted membranes (cm) and virus particles. Vinblastine sulphate which disrupts microtubulin, had an inhibitory effect on the virus production when added during the viral latent period. When infected samples were extracted with Triton X-100 and analysed by SDS-PAGE, four viral proteins were observed.
摘要
昆金（KUN）病毒感染后15小时会诱导微管蛋白副晶体（Pc）形成，且这些副晶体常与卷曲膜（cm）和病毒颗粒相关。硫酸长春碱可破坏微管蛋白，在病毒潜伏期添加时，对病毒产生具有抑制作用。用Triton X-100提取感染样本并通过SDS-PAGE分析时，可观察到四种病毒蛋白。
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