Lijftogt N, Vahl A C, Wilschut E D, Elsman B H P, Amodio S, van Zwet E W, Leijdekkers V J, Wouters M W J M, Hamming J F
Department of Vascular Surgery, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Department of Surgery, OLVG, Oosterpark 9, 1091 AC, Amsterdam, The Netherlands.
Eur J Vasc Endovasc Surg. 2017 Apr;53(4):520-532. doi: 10.1016/j.ejvs.2016.12.037. Epub 2017 Feb 28.
OBJECTIVE/BACKGROUND: The Dutch Surgical Aneurysm Audit (DSAA) is mandatory for all patients with primary abdominal aortic aneurysms (AAAs) in the Netherlands. The aims are to present the observed outcomes of AAA surgery against the predicted outcomes by means of V-POSSUM (Vascular-Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity). Adjusted mortality was calculated by the original and re-estimated V(physiology)-POSSUM for hospital comparisons.
All patients operated on from January 2013 to December 2014 were included for analysis. Calibration and discrimination of V-POSSUM and V(p)-POSSUM was analysed. Mortality was benchmarked by means of the original V(p)-POSSUM formula and risk-adjusted by the re-estimated V(p)-POSSUM on the DSAA.
In total, 5898 patients were included for analysis: 4579 with elective AAA (EAAA) and 1319 with acute abdominal aortic aneurysm (AAAA), acute symptomatic (SAAA; n = 371) or ruptured (RAAA; n = 948). The percentage of endovascular aneurysm repair (EVAR) varied between hospitals but showed no relation to hospital volume (EAAA: p = .12; AAAA: p = .07). EAAA, SAAA, and RAAA mortality was, respectively, 1.9%, 7.5%, and 28.7%. Elective mortality was 0.9% after EVAR and 5.0% after open surgical repair versus 15.6% and 27.4%, respectively, after AAAA. V-POSSUM overestimated mortality in most EAAA risk groups (p < .01). The discriminative ability of V-POSSUM in EAAA was moderate (C-statistic: .719) and poor for V(p)-POSSUM (C-statistic: .665). V-POSSUM in AAAA repair overestimated in high risk groups, and underestimated in low risk groups (p < .01). The discriminative ability in AAAA of V-POSSUM was moderate (.713) and of V(p)-POSSUM poor (.688). Risk adjustment by the re-estimated V(p)-POSSUM did not have any effect on hospital variation in EAAA but did in AAAA.
Mortality in the DSAA was in line with the literature but is not discriminative for hospital comparisons in EAAA. Adjusting for V(p)-POSSUM, revealed no association between hospital volume and treatment or outcome. Risk adjustment for case mix by V(p)-POSSUM in patients with AAAA has been shown to be important.
目的/背景:荷兰外科动脉瘤审计(DSAA)对荷兰所有原发性腹主动脉瘤(AAA)患者来说是强制性的。其目的是通过V-POSSUM(血管生理和手术严重程度评分系统,用于计算死亡率和发病率)来呈现AAA手术的观察结果与预测结果。通过原始的和重新估计的V(生理)-POSSUM计算调整后的死亡率,用于医院间比较。
纳入2013年1月至2014年12月期间接受手术的所有患者进行分析。分析V-POSSUM和V(p)-POSSUM的校准和辨别能力。通过原始的V(p)-POSSUM公式对死亡率进行基准化,并在DSAA上通过重新估计的V(p)-POSSUM进行风险调整。
总共纳入5898例患者进行分析:4579例择期AAA(EAAA)患者和1319例急性腹主动脉瘤(AAAA)患者,包括急性症状性(SAAA;n = 371)或破裂性(RAAA;n = 948)。血管内动脉瘤修复(EVAR)的比例在不同医院之间有所不同,但与医院规模无关(EAAA:p = 0.12;AAAA:p = 0.07)。EAAA、SAAA和RAAA的死亡率分别为1.9%、7.5%和28.7%。EVAR后择期死亡率为0.9%,开放手术修复后为5.0%,而AAAA后分别为15.6%和27.4%。V-POSSUM在大多数EAAA风险组中高估了死亡率(p < 0.01)。V-POSSUM在EAAA中的辨别能力中等(C统计量:0.719),而V(p)-POSSUM较差(C统计量:0.665)。AAAA修复中的V-POSSUM在高风险组中高估,在低风险组中低估(p < 0.01)。V-POSSUM在AAAA中的辨别能力中等(0.713),V(p)-POSSUM较差(0.688)。通过重新估计的V(p)-POSSUM进行风险调整对EAAA的医院差异没有任何影响,但对AAAA有影响。
DSAA中的死亡率与文献一致,但在EAAA中对医院比较没有辨别力。根据V(p)-POSSUM进行调整后,未发现医院规模与治疗或结果之间存在关联。已证明对AAAA患者通过V(p)-POSSUM对病例组合进行风险调整很重要。