Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, P.zza San Silvestro, 12 - 56126, Pisa (PI), Italy.
NEST, Scuola Normale Superiore, P.zza San Silvestro, 12 - 56126, Pisa (PI), Italy.
Sci Rep. 2017 Mar 3;7:43795. doi: 10.1038/srep43795.
Noble metal nanostructures have demonstrated a number of intriguing features for both medicine and catalysis. However, accumulation issues have prevented their clinical translation, while their use in catalysis has shown serious efficiency and stability hurdles. Here we introduce a simple and robust synthetic protocol for passion fruit-like nano-architectures composed by a silica shell embedding polymeric arrays of ultrasmall noble metal nanoparticles. These nano-architectures show interesting features for both oncology and catalysis. They avoid the issue of persistence in organism thanks to their fast biodegradation in renal clearable building blocks. Furthermore, their calcination results in yolk-shell structures composed by naked metal or alloy nanospheres shielded from aggregation by a silica shell.
贵金属纳米结构在医学和催化领域都表现出了许多有趣的特性。然而，由于存在蓄积问题，它们的临床应用受到了阻碍，而在催化领域，它们的使用也面临着严重的效率和稳定性障碍。在这里，我们介绍了一种简单而强大的合成方案，用于制备西番莲果状纳米结构，该结构由嵌入了超小贵金属纳米粒子的聚合物阵列的二氧化硅壳组成。这些纳米结构在肿瘤学和催化领域都具有有趣的特性。由于它们可以快速生物降解为可在肾脏中清除的构建块，因此避免了在生物体内持续存在的问题。此外，它们的煅烧会产生由裸露的金属或合金纳米球组成的蛋黄壳结构，这些纳米球被二氧化硅壳屏蔽，防止聚集。
