Asadi Somayeh, Korganbayev Sanzhar, Xu Wujun, Mapanao Ana Katrina, Voliani Valerio, Lehto Vesa-Pekka, Saccomandi Paola
Department of Mechanical Engineering, Politecnico di Milano, 20156 Milan, Italy.
Department of Applied Physics, University of Eastern Finland, 70211 Kuopio, Finland.
Nanomaterials (Basel). 2022 Mar 13;12(6):945. doi: 10.3390/nano12060945.
Many efforts have recently concentrated on constructing and developing nanoparticles (NPs) as promising thermal agent for optical hyperthermia and photothermal therapy. However, thermal energy transfer in biological tissue is a complex process involving different mechanisms such as conduction, convection, radiation. Therefore, having information about thermal properties of tissue especially when NPs are embedded in is a necessity for predicting the heat transfer during hyperthermia. In this work, the thermal properties of solid phantom based on agar in the presence of three different nanoparticles (BPSi, tNAs, GNRs) and alone were measured and reported as a function of temperature (ranging from 22 to 62 °C). The thermal response of these NPs to an 808 nm laser beam with three different powers were studied in the water comparatively. Agar and tNAs have almost constant thermal properties in the considered range. Among the three NPs, gold has the highest conductivity and diffusivity. At 62 °C BPSi NPs have the similar amount of increase for the diffusivity. The thermal parameters reported in this paper can be useful for the mathematical modeling. Irradiation of the NPs-loaded water phantom displayed the highest radiosensitivity of gold among the three mentioned NPs. However, for the higher power of irradiation, BPSi and tNAs NPs showed the increased absorption of heat during shorter time and the increased temperature gradient slope for the initial 15 s after the irradiation started. The three NPs showed different thermal and irradiation response behavior; however, this comparison study notes the worth of having information about thermal parameters of NPs-loaded tissue for pre-clinical planning.
最近，许多努力都集中在构建和开发纳米颗粒（NPs）上，将其作为用于光热疗和光热疗法的有前景的热介质。然而，生物组织中的热能传递是一个复杂的过程，涉及传导、对流、辐射等不同机制。因此，了解组织的热特性，尤其是当纳米颗粒嵌入其中时，对于预测热疗过程中的热传递是必要的。在这项工作中，测量并报告了基于琼脂的固体模型在存在三种不同纳米颗粒（BPSi、tNAs、GNRs）时以及单独存在时的热特性，作为温度（范围为22至62°C）的函数。在水中比较研究了这些纳米颗粒对三种不同功率的808nm激光束的热响应。在考虑的范围内，琼脂和tNAs的热特性几乎恒定。在这三种纳米颗粒中，金具有最高的电导率和扩散率。在62°C时，BPSi纳米颗粒的扩散率增加量相似。本文报道的热参数可用于数学建模。负载纳米颗粒的水体模的辐照显示，在上述三种纳米颗粒中，金具有最高的放射敏感性。然而，对于更高的辐照功率，BPSi和tNAs纳米颗粒在较短时间内显示出热量吸收增加，并且在辐照开始后的最初15秒内温度梯度斜率增加。这三种纳米颗粒表现出不同的热和辐照响应行为；然而，这项比较研究指出了了解负载纳米颗粒组织的热参数对于临床前规划的价值。
