School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210089, People's Republic of China.
Nanotechnology. 2017 Apr 21;28(16):165102. doi: 10.1088/1361-6528/aa645f. Epub 2017 Mar 3.
The near-infrared (NIR)-mediated novel strategy to control the drug release from nanocarriers has developed rapidly in recent decades. Polyaniline as a non-cytotoxic and electroactive material for studying cellular proliferation has attracted great attention in recent years. In the present work, polyaniline-mediated polymeric nanoparticles were developed to target the delivery of cisplatin and release it in a controllable way. The prepared polyaniline nanoparticles displayed a size of 90 ± 1.0 nm, a favorable morphology in water, and could be targeted to tumors through the high affinity between trastuzumab and the overexpressed Her2 in tumor cells. In addition, the developed nanoparticles demonstrated exciting photothermal conversion efficiency induced by NIR light and achieved significant cell inhibition efficiency (93.97%) in vitro when exposed to an 808 nm NIR laser with the power of 1.54 W for 5 min. Therefore, the developed external control release delivery system with excellent specificity and high cytotoxicity exhibited great potential in cell research and our research demonstrated that the polyaniline also has potential in the application of photothermal conversion in biomedicine.
近红外（NIR）介导的新型策略使纳米载体的药物释放得到了快速发展。聚[亚胺（PANI）]作为一种非细胞毒性和电活性材料，用于研究细胞增殖，近年来引起了极大关注。在本工作中，开发了聚[亚胺（PANI）]介导的聚合物纳米颗粒，以靶向递送电化疗药物顺铂，并实现其可控释放。所制备的聚[亚胺（PANI）]纳米颗粒粒径为 90 ± 1.0 nm，在水中呈现出良好的形态，并且能够通过曲妥珠单抗与肿瘤细胞中过表达的 Her2 之间的高亲和力靶向肿瘤。此外，所开发的纳米颗粒在近红外光照射下表现出令人兴奋的光热转换效率，当用 1.54 W 的 808 nm 近红外激光照射 5 分钟时，在体外实现了显著的细胞抑制效率（93.97%）。因此，这种具有优异特异性和高细胞毒性的外部控制释放递送系统在细胞研究中具有巨大的潜力，我们的研究表明聚[亚胺（PANI）]在生物医学中的光热转换应用中也具有潜力。
