Lukas S E, Mendelson J H
Harvard Medical School/McLean Hospital, Boston, MA.
Biol Psychiatry. 1988 Jan 15;23(2):141-8. doi: 10.1016/0006-3223(88)90084-4.
Covariance of brain electrical activity (EEG), plasma adrenocorticotrophic hormone (ACTH) and cortisol levels, and mood states were determined for healthy adult men during the first 2 hr after ingestion of ethanol or ethanol placebo under controlled double-blind conditions. Analysis of integrated plasma ACTH and cortisol levels at 5-min intervals, EEG power spectral analysis during consecutive 2-min epochs, and continuous assessment of mood states with a nonverbal instrumental device were carried out during the ascending phase of the blood ethanol curve. Ethanol induced rapid changes in brain electrical activity and plasma ACTH levels that were significantly correlated with subjective perception of changes in mood. The paroxysmal short epochs of euphoria associated with electroencephalographic and ACTH responses during the ascending phase of the blood ethanol curve may reflect physiological concomitants of pharmacological and behavioral reinforcers that enhance risk for perpetuation of drinking and alcohol abuse.
在受控双盲条件下，测定了健康成年男性在摄入乙醇或乙醇安慰剂后的最初2小时内脑电活动（脑电图）、血浆促肾上腺皮质激素（ACTH）和皮质醇水平以及情绪状态的协方差。在血液乙醇曲线的上升阶段，每隔5分钟分析一次血浆ACTH和皮质醇的综合水平，连续2分钟时段进行脑电图功率谱分析，并用非语言仪器设备持续评估情绪状态。乙醇引起脑电活动和血浆ACTH水平的快速变化，这些变化与情绪变化的主观感受显著相关。在血液乙醇曲线上升阶段，与脑电图和ACTH反应相关的阵发性短暂欣快期可能反映了药物和行为强化剂的生理伴随现象，这些强化剂会增加饮酒和酒精滥用持续存在的风险。
