Lukas S E, Mendelson J H, Benedikt R A, Jones B
Pharmacol Biochem Behav. 1986 Oct;25(4):889-95. doi: 10.1016/0091-3057(86)90403-x.
The effects of acute ethanol administration were studied in 18 men to determine the electroencephalographic (EEG) correlates of ethanol-induced behavioral changes. Subjects were instructed to operate an instrumental device to indicate changes in their subjective mood state while EEG activity and plasma ethanol levels were continuously measured. Three groups of 6 subjects consumed either placebo, 0.347 g/kg ethanol or 0.695 g/kg ethanol over a 15 min period. EEG and behavioral changes were directly correlated with plasma ethanol levels during the ascending limb of the plasma ethanol curve. Theta EEG activity increased proportionally as plasma ethanol levels increased during the 2 hr recording session. Alpha EEG activity increased during the first hour and then returned to control levels. The increased alpha activity was most prominent when subjects reported feeling intense pleasure or euphoria. Power spectral analysis of discrete samples of EEG activity revealed that transient increases in alpha activity paralleled the onset of ethanol-induced euphoria. These data suggest that ethanol-induced behavioral effects are associated with discrete changes in brain electrical activity.
对18名男性进行了急性乙醇给药效果的研究，以确定乙醇诱导的行为变化的脑电图（EEG）相关性。受试者被要求操作一个仪器设备来表明他们主观情绪状态的变化，同时持续测量脑电图活动和血浆乙醇水平。三组各6名受试者在15分钟内分别服用安慰剂、0.347克/千克乙醇或0.695克/千克乙醇。在血浆乙醇曲线的上升阶段，脑电图和行为变化与血浆乙醇水平直接相关。在2小时的记录过程中，随着血浆乙醇水平的升高，θ波脑电图活动成比例增加。α波脑电图活动在第一个小时增加，然后恢复到对照水平。当受试者报告感到强烈愉悦或欣快时，增加的α波活动最为明显。对脑电图活动离散样本的功率谱分析显示，α波活动的短暂增加与乙醇诱导的欣快感的发作平行。这些数据表明，乙醇诱导的行为效应与脑电活动的离散变化有关。
