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肺癌和 COPD 患者死亡地点的差异:使用死亡证明数据的 14 国研究。

Differences in place of death between lung cancer and COPD patients: a 14-country study using death certificate data.

机构信息

Vrije Universiteit Brussel (VUB) and Ghent University, End-of-Life Care Research Group, Brussels, Belgium.

Department of Family Medicine and Chronic Care, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

出版信息

NPJ Prim Care Respir Med. 2017 Mar 3;27(1):14. doi: 10.1038/s41533-017-0017-y.

Abstract

UNLABELLED

Chronic obstructive pulmonary disease and lung cancer are leading causes of death with comparable symptoms at the end of life. Cross-national comparisons of place of death, as an important outcome of terminal care, between people dying from chronic obstructive pulmonary disease and lung cancer have not been studied before. We collected population death certificate data from 14 countries (year: 2008), covering place of death, underlying cause of death, and demographic information. We included patients dying from lung cancer or chronic obstructive pulmonary disease and used descriptive statistics and multivariable logistic regressions to describe patterns in place of death. Of 5,568,827 deaths, 5.8% were from lung cancer and 4.4% from chronic obstructive pulmonary disease. Among lung cancer decedents, home deaths ranged from 12.5% in South Korea to 57.1% in Mexico, while hospital deaths ranged from 27.5% in New Zealand to 77.4% in France. In chronic obstructive pulmonary disease patients, the proportion dying at home ranged from 10.4% in Canada to 55.4% in Mexico, while hospital deaths ranged from 41.8% in Mexico to 78.9% in South Korea. Controlling for age, sex, and marital status, patients with chronic obstructive pulmonary disease were significantly less likely die at home rather than in hospital in nine countries. Our study found in almost all countries that those dying from chronic obstructive pulmonary disease as compared with those from lung cancer are less likely to die at home and at a palliative care institution and more likely to die in a hospital or a nursing home. This might be due to less predictable disease trajectories and prognosis of death in chronic obstructive pulmonary disease.

LUNG DISEASE

IMPROVING END-OF-LIFE CARE: Structured palliative care similar to that offered to cancer sufferers should be in place for patients with chronic lung disease. Joachim Cohen at Vrije University in Brussels and co-workers examined international death certificate data collected from 14 countries to determine place of death for patients with lung cancer and chronic obstructive pulmonary disease (COPD). While patients with COPD suffer similar symptoms to lung cancer in their final days, few COPD patients receive palliative care or achieve the common wish of dying at home. This may be partly due to the inherent unpredictability of final-stage COPD compared with lung cancer. Cohen's team found that, with the exception of Italy, Spain, and Mexico, patients with COPD were significantly more likely to die in hospital than at home. They highlight the need for improved COPD palliative care provision.

摘要

背景

慢性阻塞性肺疾病和肺癌是导致死亡的主要原因,两者在生命末期的症状相似。在国际范围内,对于死于慢性阻塞性肺疾病和肺癌的患者,其临终关怀的重要结局之一——死亡地点,尚未进行过比较。

方法

我们从 14 个国家(年份:2008 年)收集了人口死亡证明数据,涵盖死亡地点、根本死因和人口统计学信息。我们纳入了死于肺癌或慢性阻塞性肺疾病的患者,并使用描述性统计和多变量逻辑回归来描述死亡地点的模式。在 5568827 例死亡中,5.8%死于肺癌,4.4%死于慢性阻塞性肺疾病。在肺癌患者中,在家中死亡的比例从韩国的 12.5%到墨西哥的 57.1%不等,而在医院死亡的比例从新西兰的 27.5%到法国的 77.4%不等。在慢性阻塞性肺疾病患者中,在加拿大,有 10.4%的患者在家中死亡,而在墨西哥则有 55.4%的患者在家中死亡,而在墨西哥,有 41.8%的患者在医院死亡,在韩国则有 78.9%的患者在医院死亡。在控制年龄、性别和婚姻状况后,在 9 个国家中,患有慢性阻塞性肺疾病的患者在家中而不是在医院死亡的可能性显著降低。

结果

我们的研究发现,在几乎所有国家,与死于肺癌的患者相比,死于慢性阻塞性肺疾病的患者在家中、姑息治疗机构死亡的可能性较低,而在医院或疗养院死亡的可能性较高。这可能是由于慢性阻塞性肺疾病的疾病轨迹和死亡预测性较差。

结论

布鲁塞尔自由大学的 Joachim Cohen 及其同事研究了从 14 个国家收集的国际死亡证明数据,以确定肺癌和慢性阻塞性肺疾病(COPD)患者的死亡地点。虽然 COPD 患者在生命的最后几天会出现与肺癌相似的症状,但很少有 COPD 患者接受姑息治疗或实现在家中死亡的共同愿望。这可能部分是由于与肺癌相比,终末期 COPD 的固有不可预测性所致。Cohen 的团队发现,除了意大利、西班牙和墨西哥,COPD 患者在医院死亡的可能性明显高于在家中死亡的可能性。他们强调需要改善 COPD 的姑息治疗服务。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ddb/5434782/e6d04629f783/41533_2017_17_Fig1_HTML.jpg

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