Establishment of a new Epstein-Barr virus-immortalized cell line from chronic lymphocytic leukemia with trisomy of chromosome 12 that produces monoclonal IgM against a sheep RBC antigen.
作者信息
Crescenzi M, Napolitano M, Carbonari M, Antonelli A, Petrinelli P, Gaetano C, Fiorilli M
机构信息
Department of Clinical Immunology, University of Rome, La Sapienza, Italy.
出版信息
Blood. 1988 Jan;71(1):9-12.
PMID:2825846
Abstract
Leukemia cells from a patient with chronic lymphocytic leukemia (CLL) were found to bind sheep RBC (SRBC) through their monoclonal surface IgM. A lymphoblastoid cell line was obtained by immortalization of leukemic cells with Epstein-Barr virus (EBV). Cultured leukemic cells were found to have a supernumerary chromosome 12, an abnormality typical of CLL of the B cell type. To our knowledge, this is the first EBV-immortalized cell line from B-CLL cells of known SRBC specificity and the third reported CLL cell line carrying trisomy of chromosome 12.
摘要
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