Crescenzi M, Napolitano M, Carbonari M, Antonelli A, Petrinelli P, Gaetano C, Fiorilli M
Department of Clinical Immunology, University of Rome, La Sapienza, Italy.
Blood. 1988 Jan;71(1):9-12.
Leukemia cells from a patient with chronic lymphocytic leukemia (CLL) were found to bind sheep RBC (SRBC) through their monoclonal surface IgM. A lymphoblastoid cell line was obtained by immortalization of leukemic cells with Epstein-Barr virus (EBV). Cultured leukemic cells were found to have a supernumerary chromosome 12, an abnormality typical of CLL of the B cell type. To our knowledge, this is the first EBV-immortalized cell line from B-CLL cells of known SRBC specificity and the third reported CLL cell line carrying trisomy of chromosome 12.
