Caligaris-Cappio F, Bergui L, Rege-Cambrin G, Tesio L, Migone N, Malavasi F
Leuk Res. 1987;11(7):579-88. doi: 10.1016/0145-2126(87)90029-4.
A lymphoid cell line was established from a patient with B-cell chronic lymphocytic leukaemia (B-CLL) by infecting blood lymphocytes with Epstein-Barr virus (EBV). Immunoglobulin gene rearrangement studies and the presence of a chromosome marker (isochromosome 17q) provided the formal proof that the line has originated from the neoplastic B cells. The morphology and phenotype indicate that the EBV-induced cell line has reached a plasma cell-like stage of differentiation.
