消化系统中的水通道蛋白。

Aquaporins in Digestive System.

作者信息

Zhu Shuai, Ran Jianhua, Yang Baoxue, Mei Zhechuan

机构信息

Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.

Department of Anatomy and Neuroscience Center, Chongqing Medical University, Chongqing, 400016, China.

出版信息

Adv Exp Med Biol. 2017;969:123-130. doi: 10.1007/978-94-024-1057-0_8.

DOI:10.1007/978-94-024-1057-0_8

PMID:28258570

Abstract

In this chapter, we mainly discuss the expression and function of aquaporins (AQPs ) expressed in digestive system . AQPs in gastrointestinal tract include four members of aquaporin subfamily: AQP1, AQP4, AQP5 and AQP8, and a member of aquaglyceroporin subfamily: AQP3. In the digestive glands, especially the liver, we discuss three members of aquaporin subfamily: AQP1, AQP5 and AQP8, a member of aquaglyceroporin subfamily: AQP9. AQP3 is involved in the diarrhea and inflammatory bowel disease; AQP5 is relevant to gastric carcinoma cell proliferation and migration; AQP9 plays considerable role in glycerol metabolism , urea transport and hepatocellular carcinoma. Further investigation is necessary for specific locations and functions of AQPs in digestive system.

摘要

在本章中，我们主要讨论水通道蛋白（AQPs）在消化系统中的表达及功能。胃肠道中的水通道蛋白包括水通道蛋白亚家族的四个成员：AQP1、AQP4、AQP5和AQP8，以及水甘油通道蛋白亚家族的一个成员：AQP3。在消化腺，尤其是肝脏中，我们讨论水通道蛋白亚家族的三个成员：AQP1、AQP5和AQP8，水甘油通道蛋白亚家族的一个成员：AQP9。AQP3与腹泻和炎症性肠病有关；AQP5与胃癌细胞的增殖和迁移相关；AQP9在甘油代谢、尿素转运及肝细胞癌中发挥重要作用。有必要对水通道蛋白在消化系统中的具体定位和功能做进一步研究。