College of Pharmacy, Central South University, Changsha 410013, PR China; College of Pharmacy, Xiangnan University, Chenzhou 423043, PR China.
College of Pharmacy, Central South University, Changsha 410013, PR China.
Biomed Pharmacother. 2017 May;89:544-548. doi: 10.1016/j.biopha.2017.01.040. Epub 2017 Mar 1.
Bioassay-guided fractionation of the aerial part of P. cablin revealed that fraction A3 of the water extract exhibited significant xanthine oxidase inhibitory activities (IC=85.42±1.71μg/mL), which further led to the isolation of ten more bioactive compounds, including two new compounds (1 and 2). The structures of compounds 1 and 2 were elucidated by extensive spectral analysis. It is revealed that flavonoids and phenolic compounds were found to be responsible for the xanthine oxidase inhibitory activities of P. cablin. Especially, rosmarinic acid was found to be with potent XO inhibitory activity (IC=8.53±0.91μg/mL).
生物活性导向分离蓬莪术地上部分的水提取物得到 A3 级分，其表现出显著的黄嘌呤氧化酶抑制活性（IC=85.42±1.71μg/mL），进一步分离得到十种具有生物活性的化合物，包括两种新化合物（1 和 2）。通过广泛的光谱分析阐明了化合物 1 和 2 的结构。结果表明，类黄酮和酚类化合物是蓬莪术黄嘌呤氧化酶抑制活性的物质基础。特别地，迷迭香酸表现出很强的 XO 抑制活性（IC=8.53±0.91μg/mL）。
