Qin Jie, Li Wan, Gao Shou-Jiang, Lu Chun
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, P.R. China; Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, P.R. China; Department of Microbiology, Nanjing Medical University, Nanjing 211166, P.R. China.
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Trends Microbiol. 2017 Aug;25(8):648-661. doi: 10.1016/j.tim.2017.02.002. Epub 2017 Mar 2.
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS), a vascular tumor frequently found in immunodeficient individuals. KSHV encodes 12 pre-microRNAs (pre-miRNAs), which are processed into 25 mature microRNAs (miRNAs). KSHV miRNAs maintain KSHV latency, enhance angiogenesis and dissemination of the infected cells, and interfere with the host immune system by regulating viral and cellular gene expression, ultimately contributing to KS development. In this review, we briefly introduce the biogenesis of miRNAs and then describe the recent advances in defining the roles and mechanisms of action of KSHV miRNAs in KS development.
卡波西肉瘤相关疱疹病毒（KSHV）是卡波西肉瘤（KS）的病原体，卡波西肉瘤是一种常见于免疫缺陷个体的血管肿瘤。KSHV编码12种前体微小RNA（pre-miRNA），这些前体微小RNA被加工成25种成熟的微小RNA（miRNA）。KSHV miRNA维持KSHV潜伏状态，增强受感染细胞的血管生成和扩散，并通过调节病毒和细胞基因表达干扰宿主免疫系统，最终促成KS的发展。在本综述中，我们简要介绍了miRNA的生物合成，然后描述了在确定KSHV miRNA在KS发展中的作用和作用机制方面的最新进展。
