卡波西肉瘤相关疱疹病毒微小RNA：恶魔的把戏
KSHV microRNAs: Tricks of the Devil.
作者信息
Qin Jie, Li Wan, Gao Shou-Jiang, Lu Chun
机构信息
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, P.R. China; Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, P.R. China; Department of Microbiology, Nanjing Medical University, Nanjing 211166, P.R. China.
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
出版信息
Trends Microbiol. 2017 Aug;25(8):648-661. doi: 10.1016/j.tim.2017.02.002. Epub 2017 Mar 2.
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS), a vascular tumor frequently found in immunodeficient individuals. KSHV encodes 12 pre-microRNAs (pre-miRNAs), which are processed into 25 mature microRNAs (miRNAs). KSHV miRNAs maintain KSHV latency, enhance angiogenesis and dissemination of the infected cells, and interfere with the host immune system by regulating viral and cellular gene expression, ultimately contributing to KS development. In this review, we briefly introduce the biogenesis of miRNAs and then describe the recent advances in defining the roles and mechanisms of action of KSHV miRNAs in KS development.
摘要
卡波西肉瘤相关疱疹病毒（KSHV）是卡波西肉瘤（KS）的病原体，卡波西肉瘤是一种常见于免疫缺陷个体的血管肿瘤。KSHV编码12种前体微小RNA（pre-miRNA），这些前体微小RNA被加工成25种成熟的微小RNA（miRNA）。KSHV miRNA维持KSHV潜伏状态，增强受感染细胞的血管生成和扩散，并通过调节病毒和细胞基因表达干扰宿主免疫系统，最终促成KS的发展。在本综述中，我们简要介绍了miRNA的生物合成，然后描述了在确定KSHV miRNA在KS发展中的作用和作用机制方面的最新进展。
相似文献
1
KSHV microRNAs: Tricks of the Devil.卡波西肉瘤相关疱疹病毒微小RNA：恶魔的把戏
Trends Microbiol. 2017 Aug;25(8):648-661. doi: 10.1016/j.tim.2017.02.002. Epub 2017 Mar 2.
2
Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded microRNAs promote matrix metalloproteinases (MMPs) expression and pro-angiogenic cytokine secretion in endothelial cells.卡波氏肉瘤相关疱疹病毒（KSHV）编码的 microRNAs 促进血管内皮细胞中基质金属蛋白酶（MMPs）的表达和促血管生成细胞因子的分泌。
J Med Virol. 2017 Jul;89(7):1274-1280. doi: 10.1002/jmv.24773. Epub 2017 Mar 3.
3
miRNAs and their roles in KSHV pathogenesis.miRNAs 及其在 KSHV 发病机制中的作用。
Virus Res. 2019 Jun;266:15-24. doi: 10.1016/j.virusres.2019.03.024. Epub 2019 Apr 2.
4
A KSHV microRNA enhances viral latency and induces angiogenesis by targeting GRK2 to activate the CXCR2/AKT pathway.一种卡波西肉瘤相关疱疹病毒微小RNA通过靶向GRK2激活CXCR2/AKT途径增强病毒潜伏并诱导血管生成。
Oncotarget. 2016 May 31;7(22):32286-305. doi: 10.18632/oncotarget.8591.
5
Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells.卡波西肉瘤相关疱疹病毒在潜伏感染的细胞中表达一系列病毒微小RNA。
Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5570-5. doi: 10.1073/pnas.0408192102. Epub 2005 Mar 30.
6
microRNA dependent and independent deregulation of long non-coding RNAs by an oncogenic herpesvirus.一种致癌性疱疹病毒对长链非编码RNA的微小RNA依赖性和非依赖性失调
PLoS Pathog. 2017 Jul 17;13(7):e1006508. doi: 10.1371/journal.ppat.1006508. eCollection 2017 Jul.
7
Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Renders B Cells Hyperresponsive to Secondary Infections.卡波西肉瘤相关疱疹病毒潜伏部位使 B 细胞对二次感染高度敏感。
J Virol. 2018 Sep 12;92(19). doi: 10.1128/JVI.01138-18. Print 2018 Oct 1.
8
Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection.病毒微小RNA抑制胆固醇途径，且25-羟基胆固醇抑制感染。
mBio. 2017 Jul 11;8(4):e00576-17. doi: 10.1128/mBio.00576-17.
9
Altering the Anti-inflammatory Lipoxin Microenvironment: a New Insight into Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis.改变抗炎脂氧素微环境：对卡波西肉瘤相关疱疹病毒发病机制的新见解。
J Virol. 2016 Nov 28;90(24):11020-11031. doi: 10.1128/JVI.01491-16. Print 2016 Dec 15.
10
Modified Cross-Linking, Ligation, and Sequencing of Hybrids (qCLASH) Identifies Kaposi's Sarcoma-Associated Herpesvirus MicroRNA Targets in Endothelial Cells.杂交体的改良交联、连接与测序（qCLASH）鉴定内皮细胞中卡波西肉瘤相关疱疹病毒微小RNA的靶标
J Virol. 2018 Mar 28;92(8). doi: 10.1128/JVI.02138-17. Print 2018 Apr 15.
引用本文的文献
1
Primary Sequence-Intrinsic Immune Evasion by Viral Proteins Guides CTL-Based Vaccine Strategies.病毒蛋白的一级序列固有免疫逃逸指导基于细胞毒性T淋巴细胞的疫苗策略。
Viruses. 2025 Jul 24;17(8):1035. doi: 10.3390/v17081035.
2
Heterogeneous Activation of Signaling Pathways and Therapeutic Vulnerabilities in KSHV-Associated Primary Effusion Lymphoma Cell Lines.卡波西肉瘤相关原发性渗出性淋巴瘤细胞系中信号通路的异质性激活及治疗易损性
J Med Virol. 2025 Aug;97(8):e70534. doi: 10.1002/jmv.70534.
3
m5C RNA Methylation Is Dysregulated by Oncogenic Herpesviruses via c-Myc Signaling to Counteract Host Antiviral Factors.致癌性疱疹病毒通过c-Myc信号通路使m5C RNA甲基化失调以对抗宿主抗病毒因子。
bioRxiv. 2025 May 8:2025.05.07.652742. doi: 10.1101/2025.05.07.652742.
4
Extracellular viral microRNAs as biomarkers of virus infection in human cells.细胞外病毒微小RNA作为人类细胞中病毒感染的生物标志物
Mol Ther Nucleic Acids. 2024 Dec 31;36(1):102444. doi: 10.1016/j.omtn.2024.102444. eCollection 2025 Mar 11.
5
Epigenetic and epitranscriptomic regulation during oncogenic -herpesvirus infection.致癌性疱疹病毒感染期间的表观遗传和表转录组调控
Front Microbiol. 2025 Jan 7;15:1484455. doi: 10.3389/fmicb.2024.1484455. eCollection 2024.
6
Modulation of Cell Cycle Kinases by Kaposi's Sarcoma-Associated Herpesvirus.卡波西肉瘤相关疱疹病毒对细胞周期激酶的调节
J Med Virol. 2025 Jan;97(1):e70157. doi: 10.1002/jmv.70157.
7
RNA Modifications and Their Role in Regulating KSHV Replication and Pathogenic Mechanisms.RNA修饰及其在调控卡波西肉瘤相关疱疹病毒复制和致病机制中的作用。
J Med Virol. 2025 Jan;97(1):e70140. doi: 10.1002/jmv.70140.
8
A State-of-the-Art Review on the Recent Advances in Exosomes in Oncogenic Virus.关于致癌病毒中外泌体最新进展的综述
Health Sci Rep. 2024 Nov 18;7(11):e70196. doi: 10.1002/hsr2.70196. eCollection 2024 Nov.
9
Regulatory role of microRNAs in virus-mediated inflammation.微小RNA在病毒介导的炎症中的调节作用。
J Inflamm (Lond). 2024 Nov 4;21(1):43. doi: 10.1186/s12950-024-00417-7.
10
Research progress on miRNAs function in the interaction between human infectious viruses and hosts: A review.miRNAs 在人类感染性病毒与宿主相互作用中的功能研究进展：综述。
Biomol Biomed. 2024 Oct 17;24(6):1452-1462. doi: 10.17305/bb.2024.10821.
本文引用的文献
1
Virus-Mediated Alterations in miRNA Factors and Degradation of Viral miRNAs by MCPIP1.病毒介导的miRNA因子改变及MCPIP1对病毒miRNA的降解作用
PLoS Biol. 2016 Nov 28;14(11):e2000998. doi: 10.1371/journal.pbio.2000998. eCollection 2016 Nov.
2
Kaposi's Sarcoma-Associated Herpesvirus MicroRNAs Target GADD45B To Protect Infected Cells from Cell Cycle Arrest and Apoptosis.卡波西肉瘤相关疱疹病毒微小RNA靶向GADD45B以保护感染细胞免于细胞周期停滞和凋亡。
J Virol. 2017 Jan 18;91(3). doi: 10.1128/JVI.02045-16. Print 2017 Feb 1.
3
An Oncogenic Virus Promotes Cell Survival and Cellular Transformation by Suppressing Glycolysis.一种致癌病毒通过抑制糖酵解促进细胞存活和细胞转化。
PLoS Pathog. 2016 May 17;12(5):e1005648. doi: 10.1371/journal.ppat.1005648. eCollection 2016 May.
4
Kaposi's sarcoma herpesvirus (KSHV) microRNA K12-1 functions as an oncogene by activating NF-κB/IL-6/STAT3 signaling.卡波西肉瘤疱疹病毒（KSHV）的微小RNA K12-1通过激活NF-κB/IL-6/STAT3信号传导发挥癌基因的作用。
Oncotarget. 2016 May 31;7(22):33363-73. doi: 10.18632/oncotarget.9221.
5
The SH3BGR/STAT3 Pathway Regulates Cell Migration and Angiogenesis Induced by a Gammaherpesvirus MicroRNA.SH3BGR/STAT3信号通路调控γ-疱疹病毒微小RNA诱导的细胞迁移和血管生成。
PLoS Pathog. 2016 Apr 29;12(4):e1005605. doi: 10.1371/journal.ppat.1005605. eCollection 2016 Apr.
6
Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA.卡波西肉瘤相关疱疹病毒癌蛋白LANA的细胞周期调控功能
Front Microbiol. 2016 Mar 30;7:334. doi: 10.3389/fmicb.2016.00334. eCollection 2016.
7
A KSHV microRNA enhances viral latency and induces angiogenesis by targeting GRK2 to activate the CXCR2/AKT pathway.一种卡波西肉瘤相关疱疹病毒微小RNA通过靶向GRK2激活CXCR2/AKT途径增强病毒潜伏并诱导血管生成。
Oncotarget. 2016 May 31;7(22):32286-305. doi: 10.18632/oncotarget.8591.
8
A Toolbox for Herpesvirus miRNA Research: Construction of a Complete Set of KSHV miRNA Deletion Mutants.疱疹病毒微小RNA研究工具箱：一套完整的卡波西肉瘤相关疱疹病毒微小RNA缺失突变体的构建
Viruses. 2016 Feb 19;8(2):54. doi: 10.3390/v8020054.
9
Human Mesenchymal Stem Cells of Diverse Origins Support Persistent Infection with Kaposi's Sarcoma-Associated Herpesvirus and Manifest Distinct Angiogenic, Invasive, and Transforming Phenotypes.不同来源的人间充质干细胞支持卡波西肉瘤相关疱疹病毒的持续感染，并表现出不同的血管生成、侵袭和转化表型。
mBio. 2016 Jan 26;7(1):e02109-15. doi: 10.1128/mBio.02109-15.
10
A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling.一种卡波西肉瘤相关疱疹病毒微小RNA直接靶向G蛋白偶联受体激酶2，通过诱导CXCR2和激活AKT信号促进内皮细胞的迁移和侵袭。
PLoS Pathog. 2015 Sep 24;11(9):e1005171. doi: 10.1371/journal.ppat.1005171. eCollection 2015 Sep.
Zotero 插件