Furuya K, Nakamura M, Yamamoto Y, Togei K, Otsuka H
Second Department of Pathology, School of Medicine, University of Tokushima, Japan.
Cancer. 1988 Jan 1;61(1):99-105. doi: 10.1002/1097-0142(19880101)61:1<99::aid-cncr2820610117>3.0.co;2-u.
The livers of 345 autopsy cases of chronic liver disease were examined for macroregenerative nodule (MRN), a large nodular lesion more than 10 mm in diameter. A total of 86 lesions of MRN was found in 49 cases (14.2%): 32 were from 191 cases of hepatocellular carcinoma (HCC), 16 were from 148 cases of cirrhosis only, and one was from six cases of chronic hepatitis. The incidence (19.6%) and the size (12.1 mm) of MRN in macronodular type of cirrhosis were significantly higher and larger than those in other types of cirrhosis. Also, the average size of MRN lesions of cases with HCC (12 mm) was significantly larger than that of cases with cirrhosis only (10.5 mm). The incidence of liver cell dysplasia (LCD) in cases of MRN (67.3%) was significantly higher than that in cases without MRN (40.9%). The MRN lesions were divided into Type I and Type II, the latter having proliferative foci distinguishable from the surrounding tissue. Three of them contained atypical cells regarded as cancer. Type II lesions were larger in size, and cases with multiple MRN lesions were seen more frequently in cases of HCC. The average age of the patients with Type II lesion was 5 years older than those with Type I lesions. These findings suggest that MRN should not be ignored in the morphogenesis of HCC.
对345例慢性肝病尸检病例的肝脏进行了检查，以查找直径超过10 mm的大结节性病变——大再生结节（MRN）。在49例病例（14.2%）中总共发现了86个MRN病变：32个来自191例肝细胞癌（HCC），16个来自仅148例肝硬化病例，1个来自6例慢性肝炎病例。大结节型肝硬化中MRN的发生率（19.6%）和大小（12.1 mm）显著高于其他类型的肝硬化。此外，HCC病例的MRN病变平均大小（12 mm）显著大于仅肝硬化病例（10.5 mm）。MRN病例中肝细胞发育异常（LCD）的发生率（67.3%）显著高于无MRN病例（40.9%）。MRN病变分为I型和II型，后者具有与周围组织不同的增殖灶。其中3个含有被视为癌细胞的非典型细胞。II型病变尺寸更大，HCC病例中出现多个MRN病变的情况更常见。II型病变患者的平均年龄比I型病变患者大5岁。这些发现表明，在HCC的形态发生过程中，MRN不应被忽视。
