非编码 RNA 在心肌肥厚和心力衰竭中的作用。
Noncoding RNAs in Cardiac Hypertrophy and Heart Failure.
机构信息
Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Department of Pharmacology, University of California, Davis, CA 95616, USA.
出版信息
Cells. 2022 Feb 23;11(5):777. doi: 10.3390/cells11050777.
Heart failure is a major global health concern. Noncoding RNAs (ncRNAs) are involved in physiological processes and in the pathogenesis of various diseases, including heart failure. ncRNAs have emerged as critical components of transcriptional regulatory pathways that govern cardiac development, stress response, signaling, and remodeling in cardiac pathology. Recently, studies of ncRNAs in cardiovascular disease have achieved significant development. Here, we discuss the roles of ncRNAs, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) that modulate the cardiac hypertrophy and heart failure.
心力衰竭是一个全球性的重大健康问题。非编码 RNA（ncRNA）参与了各种疾病的生理过程和发病机制，包括心力衰竭。ncRNA 已成为转录调控途径的关键组成部分，这些途径调节心脏发育、应激反应、信号转导和心脏病理学中的重塑。最近，心血管疾病中 ncRNA 的研究取得了重大进展。在这里，我们讨论了 ncRNA 的作用，包括 microRNAs（miRNAs）、长非编码 RNA（lncRNA）和环状 RNA（circRNA），它们调节心肌肥厚和心力衰竭。
Zotero 插件