人胃黏膜腺苷酸环化酶。组胺和儿茶酚胺对酶活性的刺激作用。
Adenylate cyclase of human gastric mucosa. Stimulation of enzyme activity by histamine and catecholamines.
作者信息
Simon B, Kather H
出版信息
Digestion. 1977;16(1-2):175-9. doi: 10.1159/000198069.
PMID:28260
Abstract
Human gastric mucosal adenylate cyclase has been shown to be sensitive to histamine and catecholamines. Stimulation of enzyme activity by histamine and catecholamines were selectively blocked by cimetidine and propranolol, respectively. Combination of both hormones at maximally effective concentrations were additive, indicating that human gastric mucosa contains at least two separate hormone-sensitive adenylate cyclases.
摘要
已证明人胃黏膜腺苷酸环化酶对组胺和儿茶酚胺敏感。组胺和儿茶酚胺对酶活性的刺激分别被西咪替丁和普萘洛尔选择性阻断。两种激素在最大有效浓度下联合使用具有相加作用，表明人胃黏膜至少含有两种独立的激素敏感型腺苷酸环化酶。
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