Wainberg M A, Blain N, Fitz-Gibbon L
Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.
Clin Exp Immunol. 1987 Oct;70(1):136-42.
We have assessed the ability of HIV to infect cultures of peripheral blood lymphocytes derived from different healthy donors, varying in age between 20 and 76. The results indicate that cells from all of these people can be infected, although the percentage of infected cells varied from case to case. A similar variation was observed when attempts were made to infect cells from the same donor on more than one occasion. In most cases, infection by HIV led to persistence of an activated cell state, as indicated by the presence of Tac Ag or IL-2 receptor, at the cell surface. Co-incubation of HIV-infected lymphocytes with uninfected cells did not affect the ability of the latter either to respond to phytohaemagglutinin (PHA) or to express Tac Ag.
我们评估了HIV感染来自不同健康供体的外周血淋巴细胞培养物的能力，这些供体年龄在20至76岁之间。结果表明，所有这些人的细胞都能被感染，尽管感染细胞的百分比因病例而异。当多次尝试感染同一供体的细胞时，也观察到了类似的差异。在大多数情况下，HIV感染导致细胞表面持续存在活化细胞状态，这通过Tac抗原或IL-2受体的存在来表明。将HIV感染的淋巴细胞与未感染的细胞共同孵育，并不影响后者对植物血凝素（PHA）作出反应或表达Tac抗原的能力。
