Dreymueller D, Theodorou K, Donners M, Ludwig A
Institute of Pharmacology and Toxicology, Uniklinik RWTH Aachen, Aachen, Germany.
Department of Pathology, Maastricht University, LK Maastricht, Netherlands.
Mediators Inflamm. 2017;2017:9621724. doi: 10.1155/2017/9621724. Epub 2017 Feb 5.
Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesion molecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity.
细胞迁移是一个重要过程，参与器官发育、组织稳态以及各种生理过程，同时也涉及众多病理过程。基本的细胞迁移以及向趋化刺激的迁移都包括细胞极性变化和细胞骨架重排、细胞与相邻细胞的脱离、侵入以及重新附着，以及与细胞外基质的众多相互作用。免疫细胞、组织细胞或癌细胞迁移的不同步骤在时间和空间上通过生长因子、细胞因子/趋化因子、黏附分子以及这些配体的受体紧密协调。本综述描述了去整合素和金属蛋白酶如何通过对这些分子的蛋白水解切割或通过独立于蛋白水解活性的功能来干扰细胞迁移的几个步骤。
