Li Binbin, Li Qinghua, Mo Jingxin, Dai Honglian
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of TechnologyWuhan, China; Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan, China.
Department of Neurology, Affiliated Hospital of Guilin Medical University Guilin, China.
Front Pharmacol. 2017 Feb 14;8:51. doi: 10.3389/fphar.2017.00051. eCollection 2017.
Cancer stem cells (CSCs) have been reported to play critical roles in tumor initiation, propagation, and regeneration of cancer. Nano-size vehicles are employed to deliver drugs to target the CSCs for cancer therapy. Polymeric nanoparticles have been considered as the most efficient vehicles for drug delivery due to their excellent pharmacokinetic properties. The CSCs specific antibodies or ligands can be conjugated onto the surface or interior of nanoparticles to successfully target and finally eliminate CSCs. In this review, we focus on the approaches of polymeric nanoparticles design for loading drug, and their potential application for CSCs targeting in cancer therapy.
据报道，癌症干细胞（CSCs）在肿瘤的起始、增殖和再生过程中发挥着关键作用。纳米级载体被用于递送药物以靶向癌症干细胞进行癌症治疗。由于其优异的药代动力学性质，聚合物纳米颗粒被认为是最有效的药物递送载体。癌症干细胞特异性抗体或配体可以缀合到纳米颗粒的表面或内部，以成功靶向并最终消除癌症干细胞。在本综述中，我们重点关注用于负载药物的聚合物纳米颗粒设计方法，以及它们在癌症治疗中靶向癌症干细胞的潜在应用。
