Department of Medical Oncology, Cancer Center & Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People's Republic of China.
Department of Gastrointestinal Surgery, Chengdu Second People's Hospital, Chengdu, Sichuan Province, People's Republic of China.
Int J Nanomedicine. 2024 Feb 23;19:1867-1886. doi: 10.2147/IJN.S442768. eCollection 2024.
Although the frequency of bone metastases from breast cancer has increased, effective treatment is lacking, prompting the development of nanomedicine, which involves the use of nanotechnology for disease diagnosis and treatment. Nanocarrier drug delivery systems offer several advantages over traditional drug delivery methods, such as higher reliability and biological activity, improved penetration and retention, and precise targeting and delivery. Various nanoparticles that can selectively target tumor cells without causing harm to healthy cells or organs have been synthesized. Recent advances in nanotechnology have enabled the diagnosis and prevention of metastatic diseases as well as the ability to deliver complex molecular "cargo" particles to metastatic regions. Nanoparticles can modulate systemic biodistribution and enable the targeted accumulation of therapeutic agents. Several delivery strategies are used to treat bone metastases, including untargeted delivery, bone-targeted delivery, and cancer cell-targeted delivery. Combining targeted agents with nanoparticles enhances the selective delivery of payloads to breast cancer bone metastatic lesions, providing multiple delivery advantages for treatment. In this review, we describe recent advances in nanoparticle development for treating breast cancer bone metastases.
虽然乳腺癌骨转移的频率增加了，但缺乏有效的治疗方法，这促使了纳米医学的发展，纳米医学涉及使用纳米技术进行疾病诊断和治疗。与传统的药物输送方法相比，纳米载体药物输送系统具有更高的可靠性和生物活性、改善的穿透性和保留性、以及精确的靶向和输送。已经合成了各种能够选择性地靶向肿瘤细胞而不伤害健康细胞或器官的纳米颗粒。纳米技术的最新进展使得能够诊断和预防转移性疾病，并且能够将复杂的分子“货物”颗粒递送到转移性区域。纳米颗粒可以调节全身生物分布并使治疗剂靶向积累。有几种递药策略用于治疗骨转移，包括非靶向递药、骨靶向递药和癌细胞靶向递药。将靶向剂与纳米颗粒结合使用可增强有效载荷对乳腺癌骨转移灶的选择性递送，为治疗提供了多种递药优势。在这篇综述中，我们描述了用于治疗乳腺癌骨转移的纳米颗粒开发的最新进展。
