Ono Yasuki, Kikuchi Mitsuru, Nakatani Hideo, Murakami Masako, Nishisaka Manami, Muramatsu Tomoko, Munesue Toshio, Minabe Yoshio
Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Centre for Child Mental Development, Kanazawa University, Kanazawa, Japan.
Asian J Psychiatr. 2017 Feb;25:147-153. doi: 10.1016/j.ajp.2016.11.001. Epub 2016 Nov 9.
Evaluation of depressive states in children can be challenging. Most of the studies that have investigated cognitive function and cerebral blood volume changes using functional MRI (fMRI) in bipolar disorder (BD) have been confined to BDI or heterogeneous cohorts with attention-deficit/hyperactivity disorder (ADHD). This study investigated cognitive functions in adolescents with BDII and without ADHD using near-infrared spectroscopy (NIRS) and a Das-Naglieri Cognitive Assessment System (DN-CAS). Ten patients with BDII and without ADHD symptoms and 10 age- and gender-matched healthy controls were enrolled in the present study. NIRS was used to detect hemoglobin concentration changes during a verbal fluency test (VFT). In addition, the DN-CAS was used to evaluate cognitive function in four domains: planning, attention, simultaneous, and successive processing. Significant differences between the BDII and control groups in [oxy-Hb] changes during the early phase of VFT were observed in the lower prefrontal cortex but not in cognitive functioning. Furthermore, there was a significant correlation between planning and attention scores in BD subjects.
评估儿童的抑郁状态可能具有挑战性。大多数使用功能磁共振成像（fMRI）研究双相情感障碍（BD）中认知功能和脑血容量变化的研究都局限于双相情感障碍I型（BDI）或伴有注意力缺陷多动障碍（ADHD）的异质队列。本研究使用近红外光谱（NIRS）和达斯-纳吉里认知评估系统（DN-CAS）对无ADHD的BDII型青少年的认知功能进行了研究。本研究招募了10名无ADHD症状的BDII型患者以及10名年龄和性别匹配的健康对照。在言语流畅性测试（VFT）期间，使用NIRS检测血红蛋白浓度变化。此外，DN-CAS用于评估四个领域的认知功能：计划、注意力、同时性和继时性加工。在VFT早期阶段，BDII组和对照组之间在前额叶下部皮质的[氧合血红蛋白]（oxy-Hb）变化上存在显著差异，但在认知功能方面没有差异。此外，BD受试者的计划和注意力得分之间存在显著相关性。
