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皮肤点刺试验阳性的变应性鼻炎对脉络膜厚度的影响。

The effect of allergic rhinitis with positive skin prick test on choroidal thickness.

作者信息

Yenigun Alper, Elbay Ahmet, Dogan Remzi, Ozturan Orhan, Ozdemir Mehmet Hakan

机构信息

Bezmialem Vakif University, Faculty of Medicine, Department of Otorhinolaryngology, Adnan Menderes Boulevard, Vatan Street, Fatih, 34093, Istanbul, Turkey.

Bezmialem Vakif University, Faculty of Medicine, Department of Ophthalmology, Fatih, Istanbul, Turkey.

出版信息

Eur Arch Otorhinolaryngol. 2017 Jun;274(6):2477-2481. doi: 10.1007/s00405-017-4513-z. Epub 2017 Mar 6.

Abstract

Allergic rhinitis is an inflammatory disease that develops through immunoglobulin E in the rhino-ocular mucosa due to allergy. The main symptoms are runny nose, nasal congestion, sneezing and itchy nose. This study was designed to investigate the effect of allergic rhinitis on choroidal thickness. This study was planned as a case-control study. This study performed in a tertiary referral center. The study included 61 patients with allergic rhinitis and 35 healthy subjects. Patients in both groups underwent skin prick test. In allergic rhinitis patients and healthy persons; subfoveal, temporal and nasal choroidal thickness measurement was performed. The choroidal thicknesses were measured without pupil dilation using the Spectralis Optical Coherence Tomography. In the subfoveal and temporal region, choroidal tissue was followed up significantly thicker in allergic rhinitis patients statistically compared to healthy persons (p = 0.031, p = 0.049). However, no significant difference was followed up between the nasal choroidal thickness measurements statistically (p = 0.54). Runny nose (67.2%), sneeze (65.5%), stuffiness (62.2%), itching of the nose (40.9%), and nasal discharge (21.3%) complaints were observed significantly higher in the group having allergic rhinitis. The effect of allergic rhinitis on choroidal thickness were assessed and compared with the control group. Our study revealed that there was significant association between increased choroidal thickness and allergic rhinitis. Allergic sensitivity may play an important role in increased choroidal thickness.

摘要

过敏性鼻炎是一种由于过敏反应导致鼻眼黏膜中免疫球蛋白E介导的炎症性疾病。主要症状为流涕、鼻塞、打喷嚏和鼻痒。本研究旨在调查过敏性鼻炎对脉络膜厚度的影响。本研究设计为病例对照研究。研究在一家三级转诊中心进行。研究纳入了61例过敏性鼻炎患者和35名健康受试者。两组患者均接受了皮肤点刺试验。对过敏性鼻炎患者和健康人进行了黄斑中心凹下、颞侧和鼻侧脉络膜厚度测量。使用Spectralis光学相干断层扫描在未散瞳的情况下测量脉络膜厚度。在黄斑中心凹下和颞侧区域,过敏性鼻炎患者的脉络膜组织在统计学上显著厚于健康人(p = 0.031,p = 0.049)。然而,鼻侧脉络膜厚度测量在统计学上未发现显著差异(p = 0.54)。过敏性鼻炎组流涕(67.2%)、打喷嚏(65.5%)、鼻塞(62.2%)、鼻痒(40.9%)和鼻分泌物增多(21.3%)的主诉明显更高。评估了过敏性鼻炎对脉络膜厚度的影响并与对照组进行比较。我们的研究表明脉络膜厚度增加与过敏性鼻炎之间存在显著关联。过敏敏感性可能在脉络膜厚度增加中起重要作用。

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