L'Oréal Research & Innovation, Asnières-sur-Seine, France.
Exp Dermatol. 2017 Jun;26(6):472-477. doi: 10.1111/exd.13337. Epub 2017 May 9.
The hair follicle is a mini-organ endowed with a unique structure and cyclic behaviour. Despite the intense research efforts which have been devoted at deciphering the hair follicle biology over the past 70 years, one must admit that hair follicle remains an enigma. In this brief review, various aspects of hair follicle biology will be addressed, and more importantly, unsolved questions and new possible research tracks will be highlighted, including hair follicle glycobiology and exosome-mediated cell-cell interactions. Even though bricks of knowledge are solidly being acquired, an integrative picture remains to emerge. One can predict that computer science, algorithms and bioinformatics will assist in fostering our understanding hair biology.
毛囊是一种具有独特结构和周期性行为的微型器官。尽管在过去的 70 年里，人们为了解开毛囊生物学的奥秘付出了巨大的努力，但我们必须承认，毛囊仍然是一个谜。在这篇简短的综述中，将讨论毛囊生物学的各个方面，更重要的是，将强调未解决的问题和新的可能的研究方向，包括毛囊糖生物学和外泌体介导的细胞-细胞相互作用。尽管我们正在扎实地获得知识的基石，但一个综合的画面仍然有待形成。可以预测，计算机科学、算法和生物信息学将有助于促进我们对头发生物学的理解。
