GABA 受体与神经退行性疾病

GABA Receptors in Neurodegeneration.

机构信息

Department of Bioscience and Chemistry, Biomolecular Research Centre, College of Health, Wellbeing and Life Sciences at Sheffield Hallam University, Sheffield, UK.

出版信息

Curr Top Behav Neurosci. 2022;52:267-290. doi: 10.1007/7854_2021_222.

DOI:10.1007/7854_2021_222

PMID:33728599

Abstract

GABA is the main inhibitory neurotransmitter in the mammalian central nervous system (CNS) and acts via metabotropic GABA receptors. Neurodegenerative diseases are a major burden and affect an ever increasing number of humans. The actual therapeutic drugs available are partially effective to slow down the progression of the diseases, but there is a clear need to improve pharmacological treatment thus find alternative drug targets and develop newer pharmaco-treatments. This chapter is dedicated to reviewing the latest evidence about GABA receptors and their inhibitory mechanisms and pathways involved in the neurodegenerative pathologies.

摘要

GABA 是哺乳动物中枢神经系统（CNS）中的主要抑制性神经递质，通过代谢型 GABA 受体发挥作用。神经退行性疾病是一个主要负担，影响着越来越多的人类。目前可用的实际治疗药物在一定程度上有效，可以减缓疾病的进展，但显然需要改进药理学治疗，从而找到替代药物靶点并开发新的药物治疗方法。本章专门回顾了关于 GABA 受体及其在神经退行性病理中的抑制机制和途径的最新证据。