Pero Raffaela, Coretti Lorena, Nigro Ersilia, Lembo Francesca, Laneri Sonia, Lombardo Barbara, Daniele Aurora, Scudiero Olga
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II', 80131 Napoli, Italy.
CEINGE-Biotecnologie Avanzate Scarl, Via G. Salvatore 486, 80145 Napoli, Italy.
Molecules. 2017 Mar 7;22(3):424. doi: 10.3390/molecules22030424.
Antimicrobial peptides (AMPs) play a pivotal role in the innate immune responses to Helicobacter pylori (Hp) in humans. β-Defensins, a class of cationic arginine-rich AMPs, are small peptides secreted by immune cells and epithelial cells that exert antimicrobial activity against a broad spectrum of microorganisms, including Gram-positive and Gram-negative bacteria and fungi. During Hp infections, AMP expression is able to eradicate the bacteria, thereby preventing Hp infections in gastrointestinal tract. It is likely that gastric β-defensins expression is increased during Hp infection. The aim of this review is to focus on increased knowledge of the role of β-defensins in response to Hp infection. We also briefly discuss the potential use of AMPs, either alone or in combination with conventional antibiotics, for the treatment of Hp infection.
抗菌肽（AMPs）在人类对幽门螺杆菌（Hp）的固有免疫反应中起关键作用。β-防御素是一类富含阳离子精氨酸的抗菌肽，是由免疫细胞和上皮细胞分泌的小肽，对包括革兰氏阳性菌、革兰氏阴性菌和真菌在内的多种微生物具有抗菌活性。在Hp感染期间，抗菌肽的表达能够根除细菌，从而预防胃肠道中的Hp感染。Hp感染期间胃β-防御素的表达可能会增加。本综述的目的是着重增加对β-防御素在应对Hp感染中作用的认识。我们还简要讨论了抗菌肽单独或与传统抗生素联合用于治疗Hp感染的潜在用途。
