Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Helicobacter. 2019 Feb;24(1):e12555. doi: 10.1111/hel.12555. Epub 2018 Nov 15.
The emergence of antibiotic-resistant Helicobacter pylori strains in recent years has increased the need for finding an alternative in the post-antibiotic era. One of the fields being considered for this purpose is antimicrobial peptides. The aim of this review was to provide an obvious scheme from the studied anti-H. pylori peptides and to investigate their common features.
First, all of the antimicrobial peptides with their anti-H. pylori effects have been proved up to September 2018 were selected and their information including structure, mechanism of action, and function was reviewed. To achieve this, three databases of PubMed, Scopus, and Web of science were used.
A total of 9 groups containing 22 antimicrobial peptides were found with demonstrated anti-H. pylori effects. The nine groups included pexiganan, tilapia piscidins, epinecidin-1, cathelicidins, defensins, bicarinalin, odorranain-HP, PGLa-AM1, and bacteriocins. Most of the antimicrobial peptides, not all, had common features such as the ability to kill antibiotic-resistant strains, having α-helical structure, being cationic, with high positive charge and isoelectric point.
Antimicrobial peptides with anti-H. pylori effects have the potential to replace the antibiotics, especially in the post-antibiotic era, if a rapid and low-cost production method would be found.
近年来，抗生素耐药性幽门螺杆菌菌株的出现增加了在后抗生素时代寻找替代药物的需求。为此目的而考虑的一个领域是抗菌肽。本综述的目的是从已研究的抗幽门螺杆菌肽中提供一个明显的方案，并研究它们的共同特征。
首先，选择截至 2018 年 9 月所有具有抗幽门螺杆菌作用的抗菌肽，并对其结构、作用机制和功能等信息进行综述。为此，使用了三个数据库，即 PubMed、Scopus 和 Web of science。
共发现 9 组 22 种具有抗幽门螺杆菌作用的抗菌肽。这 9 组包括pexiganan、罗非鱼肽、epinecidin-1、cathelicidins、防御素、bicarinalin、odorranain-HP、PGLa-AM1 和细菌素。大多数抗菌肽（并非全部）具有共同特征，例如能够杀死抗生素耐药菌株、具有α-螺旋结构、呈阳离子性、具有高正电荷和等电点。
如果能够找到一种快速且低成本的生产方法，具有抗幽门螺杆菌作用的抗菌肽有可能替代抗生素，特别是在后抗生素时代。
