Department of Chemistry, Colorado State University, 1872 Campus Delivery, Fort Collins, CO 80523, USA.
Department of Chemistry, Colorado State University, 1872 Campus Delivery, Fort Collins, CO 80523, USA; School of Biomedical Engineering, Colorado State University, 1872 Campus Delivery, Fort Collins, CO 80523, USA.
Trends Biotechnol. 2014 Mar;32(3):140-6. doi: 10.1016/j.tibtech.2013.12.004. Epub 2014 Jan 15.
When interfaced with the biological environment, biomedical devices are prone to surface biofouling due to adhesion of microbial or thrombotic agents as a result of the foreign body response. Surface biofouling of medical devices occurs as a result of nonspecific adhesion of noxious substrates to the surface. Approaches for biofouling-resistant surfaces can be categorized as either the manipulation of surface chemical functionalities or through the incorporation of regulatory biomolecules. This review summarizes current strategies for creating biofouling-resistant surfaces based on surface hydrophilicity and charge, biomolecule functionalization, and drug elution. Reducing the foreign body response and restoring the function of cells around the device minimizes the risk of device rejection and potentially integrates devices with surrounding tissues and fluids. In addition, we discuss the use of peptides and NO as biomolecules that not only inhibit surface fouling, but also promote the integration of medical devices with the biological environment.
当与生物环境相互作用时，由于异物反应，生物医学设备容易因微生物或血栓形成剂的黏附而发生表面生物污染。医疗器械的表面生物污染是由于有害基质非特异性地黏附在表面上而产生的。抗生物污染表面的方法可以分为表面化学功能的操作或通过掺入调节生物分子。本综述总结了基于表面润湿性和电荷、生物分子功能化和药物洗脱的抗生物污染表面的当前策略。减少异物反应并恢复设备周围细胞的功能，可最大限度地降低设备排斥的风险，并有可能使设备与周围组织和液体相整合。此外，我们还讨论了肽和 NO 的使用，它们不仅可以抑制表面污染，还可以促进医疗器械与生物环境的整合。
