Lucas Alexander R, Levine Beverly J, Avis Nancy E
Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Cancer. 2017 Jul 15;123(14):2773-2780. doi: 10.1002/cncr.30641. Epub 2017 Mar 8.
Breast cancer survivors face a risk of disease recurrence and a higher risk of developing comorbidities such as cardiovascular disease when compared with the general population. Physical activity (PA) has been shown to reduce such risks. The current analyses sought to identify: 1) unique patterns of PA among breast cancer survivors; and 2) characteristics associated with the level of PA.
A total of 548 women reported PA and sociodemographic, health-related, and psychosocial factors at 3 time points, 6 months apart, after primary treatment of breast cancer. Cancer-related factors were obtained from chart reviews. Finite mixture modeling was used to examine trajectory groups of moderate-intensity to vigorous-intensity PA (MVPA) in the early posttreatment period. The authors then examined the characteristics associated with trajectory group membership.
Three groups with distinct, stable patterns of PA were identified: the low MVPA (42.5% of patients), medium MVPA (45.5% of patients), and high MVPA (12.0% of patients) groups. In a multivariable setting, compared with more active breast cancer survivors, the least active group was found to have a higher body mass index, were less likely to report alcohol consumption, were more likely to smoke cigarettes, and had worse physical functioning and vitality scores. Cancer treatment-related factors did not significantly predict group membership.
A large percentage of breast cancer survivors remain physically inactive after treatment, suggesting the need for interventions to reduce morbidity and mortality in this population. Cancer 2017;123:2773-80. © 2017 American Cancer Society.
与普通人群相比，乳腺癌幸存者面临疾病复发风险以及罹患合并症（如心血管疾病）的更高风险。体育活动已被证明可降低此类风险。当前分析旨在确定：1）乳腺癌幸存者中独特的体育活动模式；2）与体育活动水平相关的特征。
共有548名女性在乳腺癌初次治疗后的3个时间点（间隔6个月）报告了体育活动情况以及社会人口学、健康相关和心理社会因素。癌症相关因素通过病历审查获得。有限混合模型用于研究治疗后早期中等强度至高强度体育活动（MVPA）的轨迹组。作者随后研究了与轨迹组成员身份相关的特征。
确定了三组具有不同且稳定的体育活动模式的人群：低MVPA组（42.5%的患者）、中等MVPA组（45.5%的患者）和高MVPA组（12.0%的患者）。在多变量分析中，与体育活动较多的乳腺癌幸存者相比，体育活动最少的组被发现具有更高的体重指数，报告饮酒的可能性更低，吸烟的可能性更高，且身体功能和活力得分更差。癌症治疗相关因素并未显著预测轨迹组成员身份。
很大比例的乳腺癌幸存者在治疗后仍缺乏体育活动，这表明需要进行干预以降低该人群的发病率和死亡率。《癌症》2017年；123卷：2773 - 2780页。©2017美国癌症协会。
