Department of Veterans Affairs Puget Sound Health Care System,Seattle, WA 98101, USA.
J Cancer Surviv. 2010 Jun;4(2):119-27. doi: 10.1007/s11764-009-0113-2. Epub 2010 Feb 24.
Few longitudinal studies have examined physical activity (PA) levels in breast cancer survivors and how those levels change following cancer diagnosis and treatment.
We conducted a longitudinal cohort study of 315 female residents of Washington State, aged 21-74 years, diagnosed with a first primary invasive breast cancer between 2002 and 2004, and identified by a population-based cancer registry. Recreational PA was assessed for the 2-year period before diagnosis and at three intervals after diagnosis (1-12, 13-18, and 19-30 months). We calculated average metabolic equivalent task (MET) hours/wk of total, low-, moderate-, and vigorous-intensity PA.
Mean PA levels decreased by 50% in the 12 months after diagnosis relative to before diagnosis (from 18.8 to 9.2 MET-hours/wk). At 19-30 months post-diagnosis, overall PA levels had increased from the low levels reported in the first year after diagnosis, but remained approximately 3 MET-hours/wk lower than before diagnosis. Reductions were limited to moderate- and vigorous-intensity activities. Declines in PA differed according to certain characteristics of the study population, with the greatest reductions observed in women <40 years at diagnosis and with a pre-diagnosis body mass index <25 kg/m(2); these women were also more likely to report the greatest activity before diagnosis.
These results, if replicated in other studies, suggest that effective intervention strategies to increase PA in breast cancer survivors may differ according to patient characteristics.
Younger, normal weight, and relatively active women may benefit most from interventions to minimize the decline in PA following diagnosis, while women who are older, overweight, and relatively inactive at diagnosis may benefit from interventions to increase long-term PA.
很少有纵向研究调查过乳腺癌幸存者的体力活动（PA）水平，以及这些水平在癌症诊断和治疗后如何变化。
我们对华盛顿州的 315 名年龄在 21-74 岁之间的女性进行了一项纵向队列研究，这些女性在 2002 年至 2004 年间被诊断为首次原发性浸润性乳腺癌，并通过人群癌症登记处确定。在诊断前的 2 年期间和诊断后 3 个时间间隔（1-12、13-18 和 19-30 个月）评估了娱乐性 PA。我们计算了总、低、中、高强度 PA 的平均代谢当量任务（MET）小时/周。
与诊断前相比，诊断后 12 个月的 PA 水平下降了 50%（从 18.8 降至 9.2 MET 小时/周）。在诊断后 19-30 个月，整体 PA 水平从诊断后第一年报告的低水平有所增加，但仍比诊断前低约 3 MET 小时/周。这种减少仅限于中等强度和剧烈强度的活动。PA 的减少因研究人群的某些特征而异，在诊断时年龄<40 岁和诊断前 BMI<25kg/m2的女性中观察到最大减少；这些女性在诊断前也更有可能报告最大活动量。
如果在其他研究中得到复制，这些结果表明，针对乳腺癌幸存者增加 PA 的有效干预策略可能因患者特征而异。
年轻、体重正常和相对活跃的女性可能最受益于干预措施，以尽量减少诊断后 PA 的下降，而诊断时年龄较大、超重和相对不活跃的女性可能受益于干预措施，以增加长期 PA。
