Kazandjieva Jana, Tsankov Nikolay
Department of Dermatology and Venereology, Medical University, Sofia, Bulgaria.
Department of Dermatology and Venereology, Tokuda Hospital, Sofia, Bulgaria.
Clin Dermatol. 2017 Mar-Apr;35(2):156-162. doi: 10.1016/j.clindermatol.2016.10.007. Epub 2016 Oct 27.
A variety of drugs may provoke acne, with drug-induced acne (DIA) often having some specific clinical and histopathologic features. DIA is characterized by a medical history of drug intake, sudden onset, and an unusual age of onset, with a monomorphous eruption of inflammatory papules or papulopustules. The location of the acne lesions is beyond the seborrheic zone. Corticosteroids, anabolic steroids, testosterone, halogens, isoniazid, lithium, and some new anticancer agents are drugs with undoubted causal relationship to acne. The diagnosis of DIA is made by a detailed history with a record of drug onset, dosage regimen and therapy duration, absence of additional triggering factors, and clinical relationship between the introduction of the drug and the onset of an acne-like eruption. In all cases, the withdrawal of the drug should be followed by lessening of the acne lesions.
多种药物可能引发痤疮，药物性痤疮（DIA）通常具有一些特定的临床和组织病理学特征。DIA的特点是有用药病史、起病突然且发病年龄异常，表现为炎症性丘疹或丘疹脓疱的单一形态皮疹。痤疮皮损的部位超出皮脂溢出区。皮质类固醇、合成代谢类固醇、睾酮、卤素、异烟肼、锂以及一些新型抗癌药物与痤疮有明确的因果关系。DIA的诊断依据详细病史，记录用药起始时间、给药方案和治疗持续时间，不存在其他触发因素，以及用药与痤疮样皮疹发作之间的临床关联。在所有病例中，停用药物后痤疮皮损应会减轻。
