Gauquelin G, Garcia R, Carrier F, Cantin M, Gutkowska J, Thibault G, Schiffrin E L
Laboratory of Experimental Hypertension and Vasoactive Peptides, Clinical Research Institute of Montreal, Quebec, Canada.
Am J Physiol. 1988 Jan;254(1 Pt 2):F51-5. doi: 10.1152/ajprenal.1988.254.1.F51.
The concentration of atrial natriuretic factor (ANF) in atria and plasma was investigated in relation to the regulation of renal glomerular ANF receptors in the rat during changes in water and sodium intake. A decrease in plasma immunoreactive ANF (IR-ANF) was observed after 4 days of water deprivation or after 1 wk on a low-sodium diet, whereas animals offered 1% NaCl in their drinking water had elevated plasma ANF values. Atrial IR-ANF was lower in water-deprived and higher in sodium-restricted rats than in their respective controls. A low-sodium intake or water deprivation increased the density of glomerular ANF receptors, whereas the inverse occurred with a high-salt consumption. It is concluded that an inverse correlation exists between ANF plasma concentration and renal glomerular ANF receptor sites.
研究了大鼠在水和钠摄入量变化期间，心房和血浆中心房利钠因子（ANF）的浓度与肾小球ANF受体调节的关系。禁水4天后或低钠饮食1周后，血浆免疫反应性ANF（IR-ANF）降低，而饮用水中含有1% NaCl的动物血浆ANF值升高。禁水大鼠的心房IR-ANF较低，限钠大鼠的心房IR-ANF高于各自的对照组。低钠摄入或禁水增加了肾小球ANF受体的密度，而高盐摄入则出现相反的情况。得出的结论是，ANF血浆浓度与肾小球ANF受体位点之间存在负相关。
