Xu Bing, Sui Yi, Zhu Chunyan, Yang Xiaomei, Zhou Jin, Li Li, Ren Li, Wang Xu
Department of Neurology and Neuroscience, Shenyang Brain Institute, Shenyang First People's Hospital, Shenyang Brain Hospital, Shenyang, Liaoning, China.
Department of Neurology, Shenyang Seventh People's Hospital, Shenyang, Liaoning, China.
Neurol Sci. 2017 Jun;38(6):983-992. doi: 10.1007/s10072-017-2878-9. Epub 2017 Mar 8.
The background of this study is to determine whether there is an association between music intervention and cognitive dysfunction therapy in healthy older adults, and if so, whether music intervention can be used as first-line non-pharmacological treatment. The method used in this study is to conduct a systematic review and meta-analysis of clinical trials that examined the effects of music intervention on patient-relevant and disease-specific outcomes. A comprehensive literature was performed on PubMed, EMbase and the Cochrane Library from inception to September 2016. A total of 10 studies (14 analyses, 966 subjects) were included; all of them had an acceptable quality based on the PEDro scale score and CASP scale score. Compared with control group, the standardized mean difference was 0.03 (-0.18 to 0.24) for cognitive function as primary outcome by random effect model; secondary outcomes were included disruptive behavior, depressive score, anxiety and quality of life. No evidence of publication bias could be found in funnel plots, Begg's test and Egger's test. Subgroup analyses showed that intervention method, comparator, trial design, trial period and outcome measure instruments made little difference in outcomes. Meta-regression might not identify cause of heterogeneity. This study is registered with PROSPERO, number CRD442016036264. There was positive evidence to support the use of music intervention on treatment of cognitive function.
本研究的背景是确定音乐干预与健康老年人认知功能障碍治疗之间是否存在关联，若存在关联，音乐干预是否可作为一线非药物治疗方法。本研究采用的方法是对考察音乐干预对患者相关及疾病特异性结局影响的临床试验进行系统评价和荟萃分析。对PubMed、EMbase和Cochrane图书馆从建库至2016年9月的文献进行全面检索。共纳入10项研究（14项分析，966名受试者）；根据PEDro量表评分和CASP量表评分，所有研究质量均可接受。随机效应模型显示，作为主要结局的认知功能方面，与对照组相比，标准化均差为0.03（-0.18至0.24）；次要结局包括破坏性行为、抑郁评分、焦虑和生活质量。在漏斗图、Begg检验和Egger检验中均未发现发表偏倚的证据。亚组分析表明，干预方法、对照、试验设计、试验周期和结局测量工具对结局影响不大。Meta回归可能无法确定异质性的原因。本研究已在PROSPERO注册，注册号为CRD442016036264。有积极证据支持使用音乐干预治疗认知功能。
