Villanacci Vincenzo, Casella Giovanni, Lanzarotto Francesco, Di Bella Camillo, Sidoni Angelo, Cadei Moris, Salviato Tiziana, Dore Maria Pina, Bassotti Gabrio
a Pathology Section, Department of Molecular and Translational Medicine , Spedali Civili and University of Brescia , Brescia , Italy.
c Department of Medicine , Desio Hospital, Monza and Brianza , Italy.
Scand J Gastroenterol. 2017 Jun-Jul;52(6-7):674-677. doi: 10.1080/00365521.2017.1288758. Epub 2017 Feb 17.
Autoimmune gastritis (AIG) is a gastric pathologic condition affecting the mucosa of the fundus and the body and eventually leading to hypo-achlorhydria.
We report our clinical and pathological experience with AIG.
Data from patients with a diagnosis of AIG seen in the period January 2002-December 2012 were retrieved. Only patients with complete sets of biopsies were analyzed.
Data from 138 patients were available for analysis. Pernicious anemia was present in 25% of patients, iron deficiency anemia was found in 29.7% of patients, hypothyroidism in 23% of patients, type 1 diabetes in 7.9% of patients, and vitiligo in 2.8% of patients. Parietal cell antibodies were positive in 65% of patients, and no patient had serology positive for celiac disease. All gastric biopsies showed glandular atrophy associated with enterochromaffin-like (ECL)-cells hyperplasia, features limited to the mucosa of the fundus and body, and focal glandular intestinal metaplasia. Helicobacter pylori was negative in all cases.
AIG was strongly associated with anemia; atrophy, intestinal metaplasia and ECL hyperplasia in the gastric fundus and body are hallmarks of this condition.
自身免疫性胃炎（AIG）是一种影响胃底和胃体黏膜并最终导致胃酸分泌减少的胃部病理状况。
我们报告我们在AIG方面的临床和病理经验。
检索2002年1月至2012年12月期间诊断为AIG的患者的数据。仅分析有完整活检系列的患者。
138例患者的数据可供分析。25%的患者存在恶性贫血，29.7%的患者存在缺铁性贫血，23%的患者存在甲状腺功能减退，7.9%的患者存在1型糖尿病，2.8%的患者存在白癜风。65%的患者壁细胞抗体呈阳性，且无患者乳糜泻血清学呈阳性。所有胃活检均显示与肠嗜铬样（ECL）细胞增生相关的腺体萎缩，特征局限于胃底和胃体黏膜，以及局灶性腺体肠化生。所有病例幽门螺杆菌均为阴性。
AIG与贫血密切相关；胃底和胃体的萎缩、肠化生和ECL增生是这种疾病的标志。
