Wang Chuangshi, Hao Guang, Bo Jian, Li Wei
a Fuwai Hospital , National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , China.
b Georgia Prevention Institute, Department of Pediatrics , Medical College of Georgia, Augusta University , Augusta , GA , USA.
Chronobiol Int. 2017;34(5):601-608. doi: 10.1080/07420528.2017.1285785. Epub 2017 Feb 16.
Epidemiological and animal studies have suggested an association between habitual sleep patterns and cardiovascular (CV) disease, but the results are still controversial. Therefore, the aims of this study are to investigate the relationships between habitual sleep patterns and CV disease based on Prospective Urban Rural Epidemiology (PURE) China study. PURE China study recruited 46 285 participants, aged 35-70, from 12 provinces and 115 communities in China. Habitual sleep patterns and CV disease were self-reported. Multilevel logistic regression was used in our analysis. In this study, 39 515 participants were eligible in our analysis, including 23 345 (59.1%) women and 16 170 (40.9%) men. Sleeping ≥9 h per day was associated with increased odds of CV disease (OR = 1.16, 95% CI: 1.01-1.32, p = 0.033) compared with sleeping 7-8 h per day. Taking daytime naps was also associated with an increased odds of CV disease, and the CV odds increased with increasing napping duration (p for trend < 0.001). For the sleeping < 6 h per day, we only found an association with coronary artery disease (CAD) (OR = 1.58, 95% CI: 1.01-2.48, p = 0.046). Participants with only 7-8 h sleep per night had lowest prevalence of CV disease (OR = 0.77, 95% CI: 0.65-0.90, p = 0.001) compared with other sleep patterns. Napping, long and short duration of habitual sleep may increase the odds of CV disease. Only participants sleeping 7-8 hours at night are recommended in this study, and large longitudinal studies are needed to confirm these results.
流行病学和动物研究表明，习惯性睡眠模式与心血管（CV）疾病之间存在关联，但结果仍存在争议。因此，本研究旨在基于中国城乡前瞻性流行病学（PURE）研究，探讨习惯性睡眠模式与心血管疾病之间的关系。PURE中国研究从中国12个省份的115个社区招募了46285名年龄在35 - 70岁之间的参与者。习惯性睡眠模式和心血管疾病情况均通过自我报告获得。我们的分析采用多水平逻辑回归。在本研究中，39515名参与者符合分析条件，其中包括23345名（59.1%）女性和16170名（40.9%）男性。与每天睡眠7 - 8小时相比，每天睡眠≥9小时与心血管疾病风险增加相关（OR = 1.16，95% CI：1.01 - 1.32，p = 0.033）。白天午睡也与心血管疾病风险增加相关，且心血管疾病风险随着午睡时间延长而增加（趋势p < 0.001）。对于每天睡眠<6小时的情况，我们仅发现其与冠状动脉疾病（CAD）相关（OR = 1.58，95% CI：1.01 - 2.48，p = 0.046）。与其他睡眠模式相比，每晚仅睡7 - 8小时的参与者心血管疾病患病率最低（OR = 0.77，95% CI：0.65 - 0.90，p = 0.001）。午睡、习惯性睡眠时长过长或过短可能会增加心血管疾病风险。本研究仅推荐夜间睡眠7 - 8小时的参与者，需要大型纵向研究来证实这些结果。
