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肌醇给药对多囊卵巢综合征患者的促排卵和宫腔内人工授精有积极作用:一项前瞻性、对照、随机试验。

Myo-inositol administration positively effects ovulation induction and intrauterine insemination in patients with polycystic ovary syndrome: a prospective, controlled, randomized trial.

作者信息

Emekçi Özay Özlen, Özay Ali Cenk, Çağlıyan Erkan, Okyay Recep Emre, Gülekli Bülent

机构信息

a Department of Obstetrics and Gynecology , Konya Aksehir State Hospital , Konya , Turkey and.

b Department of Obstetrics and Gynecology , Dokuz Eylul University, School of Medicine , Izmir , Turkey.

出版信息

Gynecol Endocrinol. 2017 Jul;33(7):524-528. doi: 10.1080/09513590.2017.1296127. Epub 2017 Mar 3.

Abstract

UNLABELLED

Objectıve: The aim of the study is to investigate the effect of myo-inositol (MYO) on pregnancy rates of patients diagnosed with polycystic ovary syndrome (PCOS) who undergone controlled ovulation induction and intrauterine insemination (IUI).

METHODS

A total of 196 infertile patients diagnosed with PCOS and admitted to Dokuz Eylul University Faculty of Medicine were included in the study between March 2013 and May 2016. The patients in group 1 (n = 98) were given 4 g MYO and 400 μg folic acid before and during ovulation induction. The patients undergone controlled ovarian hyperstimulation (COH) with recombinant FSH and IUI. The patients in group 2 (n = 98), were given recombinant FSH directly and 400 μg folic acid. The primary outcome measure of this study was the clinical pregnancy rate.

RESULTS

In group 1, 9 patients conceived spontaneous pregnancy. During COH + IUI treatment three cycles were canceled in group 1 and 8 cycles in group 2. Total rFSH dose and cycle duration were significantly lower and clinical pregnancy rates were higher in group 1. The pregnancy rate for group 1 was %18.6 and for group 2 was %12.2. Conclusıons: This study shows that MYO should be considered in the treatment of infertile PCOS patients. MYO administration increases clinical pregnancy rates, lowers total rFSH dose and the duration of the ovulation induction.

摘要

未标注

目的:本研究旨在调查肌醇(MYO)对接受控制性促排卵和宫内人工授精(IUI)的多囊卵巢综合征(PCOS)患者妊娠率的影响。

方法

2013年3月至2016年5月期间,共有196例被诊断为PCOS的不孕患者被纳入多库兹艾吕尔大学医学院的研究。第1组(n = 98)的患者在促排卵前及促排卵期间给予4克肌醇和400微克叶酸。这些患者接受重组促卵泡激素控制性卵巢过度刺激(COH)及宫内人工授精。第2组(n = 98)的患者直接给予重组促卵泡激素和400微克叶酸。本研究的主要结局指标是临床妊娠率。

结果

第1组中有9例患者自然受孕。在COH + IUI治疗期间,第1组有3个周期取消,第2组有8个周期取消。第1组的总重组促卵泡激素剂量和周期持续时间显著更低,临床妊娠率更高。第1组的妊娠率为18.6%,第2组为12.2%。结论:本研究表明,在治疗PCOS不孕患者时应考虑使用肌醇。给予肌醇可提高临床妊娠率,降低总重组促卵泡激素剂量及促排卵持续时间。

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