Howell David N
a Department of Pathology , Duke University , Durham , NC , USA.
b Durham Veterans Affairs Medical Centers , Durham , NC , USA.
Ultrastruct Pathol. 2017 Mar-Apr;41(2):135-146. doi: 10.1080/01913123.2017.1282068. Epub 2017 Mar 1.
Kidney biopsy is a mainstay in the diagnosis and management of renal disease in patients with systemic lupus erythematosus. Though biopsies from patients with lupus typically show various forms of immune complex glomerulonephritis, other pathologies are occasionally encountered, including unusual lupus-related nephropathies, other forms of autoimmune disease, and occasional renal disorders without any direct connection with lupus or autoimmunity. Electron microscopy is a powerful tool for detecting and classifying these unusual conditions, which frequently have important therapeutic and prognostic implications.
肾活检是系统性红斑狼疮患者肾脏疾病诊断和管理的主要手段。虽然狼疮患者的活检通常显示各种形式的免疫复合物肾小球肾炎，但偶尔也会遇到其他病理情况，包括不常见的狼疮相关肾病、其他自身免疫性疾病形式，以及偶尔与狼疮或自身免疫无直接关联的肾脏疾病。电子显微镜是检测和分类这些不常见情况的有力工具，这些情况往往具有重要的治疗和预后意义。
