Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Cell Mol Biol Lett. 2021 Apr 7;26(1):13. doi: 10.1186/s11658-021-00257-w.
Cancer, as one of the main causes of human deaths, is currently a significant global health challenge. Since the majority of cancer-related deaths are associated with late diagnosis, it is necessary to develop minimally invasive early detection markers to manage and reduce mortality rates. MicroRNAs (miRNAs), as highly conserved non-coding RNAs, target the specific mRNAs which are involved in regulation of various fundamental cellular processes such as cell proliferation, death, and signaling pathways. MiRNAs can also be regulated by long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). They are highly stable in body fluids and have tumor-specific expression profiles, which suggest their suitability as efficient non-invasive diagnostic and prognostic tumor markers. Aberrant expression of miR-338 has been widely reported in different cancers. It regulates cell proliferation, migration, angiogenesis, and apoptosis in tumor cells.
In the present review, we have summarized all miR-338 interactions with other non-coding RNAs (ncRNAs) and associated signaling pathways to clarify the role of miR-338 during tumor progression.
It was concluded that miR-338 mainly functions as a tumor suppressor in different cancers. There were also significant associations between miR-338 and other ncRNAs in tumor cells. Moreover, miR-338 has a pivotal role during tumor progression using the regulation of WNT, MAPK, and PI3K/AKT signaling pathways. This review highlights miR-338 as a pivotal ncRNA in biology of tumor cells.
癌症是人类死亡的主要原因之一，目前是一个重大的全球健康挑战。由于大多数与癌症相关的死亡与晚期诊断有关，因此有必要开发微创的早期检测标志物来进行管理并降低死亡率。微小 RNA（miRNA）作为高度保守的非编码 RNA，靶向参与调节各种基本细胞过程（如细胞增殖、死亡和信号通路）的特定 mRNA。miRNA 还可以受到长链非编码 RNA（lncRNA）和环状 RNA（circRNA）的调控。它们在体液中高度稳定，并且具有肿瘤特异性的表达谱，这表明它们适合作为有效的非侵入性诊断和预后肿瘤标志物。miR-338 的异常表达在不同的癌症中被广泛报道。它调节肿瘤细胞中的细胞增殖、迁移、血管生成和凋亡。
在本综述中，我们总结了 miR-338 与其他非编码 RNA（ncRNA）的所有相互作用及其相关信号通路，以阐明 miR-338 在肿瘤进展过程中的作用。
研究得出结论，miR-338 在不同的癌症中主要作为肿瘤抑制因子发挥作用。在肿瘤细胞中，miR-338 与其他 ncRNA 之间也存在显著的关联。此外，miR-338 通过调节 WNT、MAPK 和 PI3K/AKT 信号通路在肿瘤进展中发挥关键作用。本综述强调了 miR-338 作为肿瘤细胞生物学中关键的 ncRNA 的作用。
