a Department of Pharmacology , University of California , Davis, Davis , CA , USA.
b Saniona A/S , Ballerup , Denmark.
Channels (Austin). 2017 Jul 4;11(4):305-315. doi: 10.1080/19336950.2017.1300738. Epub 2017 Mar 1.
Potassium channels play important roles in microglia functions and thus constitute potential targets for the treatment of neurodegenerative diseases like Alzheimer, Parkinson and stroke. However, uncertainty still prevails as to which potassium channels are expressed and at what levels in different species, how the expression pattern changes upon activation with M1 or M2 polarizing stimuli compared with more complex exposure paradigms, and - most importantly - how these findings relate to the in vivo situation. In this mini-review we discuss the functional potassium channel expression pattern in cultured neonatal mouse microglia in the light of data obtained previously from animal disease models and immunohistochemical studies and compare it with a recent study of adult human microglia isolated from epilepsy patients. Overall, microglial potassium channel expression is very plastic and possibly shows species differences and therefore should be studied carefully in each disease setting and respective animal models.
钾通道在小胶质细胞功能中发挥重要作用，因此成为治疗阿尔茨海默病、帕金森病和中风等神经退行性疾病的潜在靶点。然而，目前仍不确定在不同物种中表达哪些钾通道以及表达水平如何，在与更复杂的暴露范式相比，用 M1 或 M2 极化刺激激活时表达模式如何变化，以及 - 最重要的是 - 这些发现与体内情况有何关系。在这篇迷你综述中，我们根据先前从动物疾病模型和免疫组织化学研究中获得的数据，讨论了培养的新生小鼠小胶质细胞中的功能性钾通道表达模式，并将其与最近一项从癫痫患者中分离出的成人人类小胶质细胞的研究进行了比较。总体而言，小胶质细胞钾通道表达非常具有可塑性，并且可能表现出物种差异，因此应在每种疾病环境和相应的动物模型中仔细研究。
