训练免疫：一种古老的记忆方式。

Trained Immunity: An Ancient Way of Remembering.

机构信息

Department of Internal Medicine, Radboud University Medical Centre, PO box 9101, 6500HB Nijmegen, the Netherlands.

出版信息

Cell Host Microbe. 2017 Mar 8;21(3):297-300. doi: 10.1016/j.chom.2017.02.003.

DOI:10.1016/j.chom.2017.02.003

Abstract

The innate arm of the immune system has generally been regarded as primitive and non-specific and, in contrast to adaptive immunity, not to possess memory. Here we review the growing body of evidence that innate immunity has an important capacity to adapt, a de facto innate immune memory (also termed trained immunity), and this provides broad protection against infections.

摘要

免疫系统的先天免疫通常被认为是原始的和非特异性的，与适应性免疫不同，它没有记忆。在这里，我们回顾了越来越多的证据，表明先天免疫具有重要的适应能力，这实际上是一种先天免疫记忆（也称为训练有素的免疫），它为感染提供了广泛的保护。