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作为结核病疫苗研发中变革性因素的保护性免疫相关指标。

Immune correlates of protection as a game changer in tuberculosis vaccine development.

作者信息

Wang Jing, Fan Xiao-Yong, Hu Zhidong

机构信息

Shanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan University, Shanghai, 201508, China.

出版信息

NPJ Vaccines. 2024 Oct 30;9(1):208. doi: 10.1038/s41541-024-01004-w.

DOI:10.1038/s41541-024-01004-w
PMID:39478007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11526030/
Abstract

The absence of validated correlates of protection (CoPs) hampers the rational design and clinical development of new tuberculosis vaccines. In this review, we provide an overview of the potential CoPs in tuberculosis vaccine research. Major hindrances and potential opportunities are then discussed. Based on recent progress, it is reasonable to anticipate that success in the ongoing efforts to identify CoPs would be a game-changer in tuberculosis vaccine development.

摘要

缺乏经过验证的保护关联指标（CoP）阻碍了新型结核病疫苗的合理设计和临床开发。在本综述中，我们概述了结核病疫苗研究中的潜在保护关联指标。然后讨论了主要障碍和潜在机遇。基于最近的进展，有理由预计，在正在进行的确定保护关联指标的工作中取得成功将成为结核病疫苗开发的一个改变局面的因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/11526030/1bfb0938e49e/41541_2024_1004_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/11526030/e2651407406c/41541_2024_1004_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/11526030/8fdafd380caa/41541_2024_1004_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/11526030/1bfb0938e49e/41541_2024_1004_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/11526030/e2651407406c/41541_2024_1004_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/11526030/8fdafd380caa/41541_2024_1004_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/11526030/1bfb0938e49e/41541_2024_1004_Fig3_HTML.jpg

相似文献

[1]
Immune correlates of protection as a game changer in tuberculosis vaccine development.

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[2]
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[10]
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Immunol Rev. 2025-8

[2]
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[3]
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[4]
Recombinant BCGΔBCG1419c protects outbred mice against M. tuberculosis challenge.

Vaccine. 2025-8-13

[5]
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Vaccines (Basel). 2025-4-16

[6]
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[7]
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[8]
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Sci Rep. 2025-1-13

本文引用的文献

[1]
Epigenetic programming of host lipid metabolism associated with resistance to TST/IGRA conversion after exposure to .

mSystems. 2024-9-17

[2]
A multistage protein subunit vaccine as BCG-booster confers protection against Mycobacterium tuberculosis infection in murine models.

Int Immunopharmacol. 2024-9-30

[3]
Harnessing Artificial Intelligence in Multimodal Omics Data Integration: Paving the Path for the Next Frontier in Precision Medicine.

Annu Rev Biomed Data Sci. 2024-8

[4]
Whole-transcriptome sequencing of phagocytes reveals a ceRNA network contributing to natural resistance to tuberculosis infection.

Microb Pathog. 2024-7

[5]
MR1-restricted T cell clonotypes are associated with "resistance" to Mycobacterium tuberculosis infection.

JCI Insight. 2024-5-8

[6]
Review of Current Tuberculosis Human Infection Studies for Use in Accelerating Tuberculosis Vaccine Development: A Meeting Report.

J Infect Dis. 2024-8-16

[7]
Age and sex influence antibody profiles associated with tuberculosis progression.

Nat Microbiol. 2024-6

[8]
Safety of a controlled human infection model of tuberculosis with aerosolised, live-attenuated Mycobacterium bovis BCG versus intradermal BCG in BCG-naive adults in the UK: a dose-escalation, randomised, controlled, phase 1 trial.

Lancet Infect Dis. 2024-8

[9]
Effectiveness of Histopathological Examination of Ultrasound-guided Puncture Biopsy Samples for Diagnosis of Extrapulmonary Tuberculosis.

Biomed Environ Sci. 2024-2-20

[10]
Multi-omics analysis reveals that linoleic acid metabolism is associated with variations of trained immunity induced by distinct BCG strains.

Sci Adv. 2024-4-5

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